Effects of astaxanthin on biochemical and histopathological parameters related to oxidative stress on testes of rats on high fructose regime
Yazarlar (8)
Prof. Dr. Eda Dokumacıoğlu Artvin Çoruh Üniversitesi, Türkiye
Prof. Dr. Hatice İskender Artvin Çoruh Üniversitesi, Türkiye
Prof. Dr. Güler Yenice Atatürk Üniversitesi, Türkiye
Prof. Dr. Kübra Asena Terim Kapakin Atatürk Üniversitesi, Türkiye
Doç. Dr. Çiğdem SEVİM Atatürk Üniversitesi, Türkiye
Armağan Hayırlı
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Doç. Dr. Sinan Saral Recep Tayyip Erdoğan Üniversitesi, Türkiye
Doç. Dr. Selim Çomaklı Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ANDROLOGIA (Q3) | ||
| Dergi ISSN | 0303-4569 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2018 |
| Cilt / Sayı / Sayfa | 50 / 7 / 1–10 | DOI | 10.1111/and.13042 |
| Makale Linki | http://doi.wiley.com/10.1111/and.13042 | ||
| UAK Araştırma Alanları |
Tıbbi Farmakoloji
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| Özet |
| Astaxanthin (ASX) is a xanthophyll family of hydroxycarotenoids which contains several double bonds. It is produced by Haemococcus pluvialis, a microalgae and possesses antioxidant and anti-inflammatory properties. The aim of this study was to test whether ASX could protect against oxidative damage in the testicular tissues of rats receiving high fructose. The rats (n = 24) were randomly divided into two main groups: control and fructose (30%, via drinking water) and then each main group either not supplemented or supplemented with ASX (1 mg kg day , within 0.2 ml olive oil) via oral gavage. Data were subjected to two-way ANOVA. High fructose consumption tended to increase testis weight and serum testosterone concentration and decreased testicular tissue glutathione-S-transferase (GST) and superoxide dismutase (SOD) levels, but did not affect testicular tissue malondialdehyde (MDA) concentration. Astaxanthin administration increased testosterone, GST and SOD levels and testis weight and decreased MDA concentration. However, ASX administration did not reverse alterations in antioxidant parameters caused by high fructose consumption. Inducible nitric oxide synthase (iNOS) tended to increase in sertoli cell, spermatid and spermatogonia, but not in spermatocytes and leydig cell in response to high fructose consumption. Astaxanthin administration tended to reverse elevation in iNOS in testis cells. In conclusion, ASX could help alleviate oxidative damage caused by high fructose consumption. |
| Anahtar Kelimeler |
| astaxanthin | fructose | oxidative stress | testes |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 29 |