| Yazarlar |
Dr. Öğr. Üyesi Çiğdem SEVİM
Atatürk Üniversitesi, Türkiye |
Selim Çomaklı
Atatürk Üniversitesi, Türkiye |
|
Ali Taghizadehghalehjoughi
|
|
Mustafa Özkaraca
Atatürk Üniversitesi, Türkiye |
|
Robin Mesnage
|
|
Leda Kovatsi
|
|
Tatyana I. Burykına
|
|
Alexandra Kalogerakı
|
|
Mıchael N. Antonıou
|
|
Arıstıdıs Tsatsakıs
|
| Özet |
| We studied the acute toxicity of an imazamox-based herbicide at 12, 24 and 36 mg/kg body (bw) weight imazamox equivalent dose on the liver and pancreatic tissue in Sprague Dawley rats. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, glucose, calcium as well as creatinine, were determined in blood samples, which were collected after 24, 48 and 72 h exposure. Caspase 3 and anti-insulin expression and immunopositivity were evaluated using in situ hybridization and immunohistochemistry, respectively. The imazamox-based herbicide evaluated in this study induced toxic effects even from the lowest dose tested (12 mg/kg bw). The two highest doses caused a statistically significant cytotoxicity on the Langerhans islet cells. Necrotic and degenerative changes were detected in hepatocytes at the two highest doses. Imazamox is considered to be poorly toxic to the liver. Nevertheless, the imazamox-based herbicide formulation tested here reduced the size of the β-islet cells, induced an elevation in serum glucose and calcium. Our data shows that commercial formulations of imazamox containing various co-formulants can have hepatic and pancreatic toxic effects. |
| Anahtar Kelimeler |
| Anti-insulin,Caspase 3,Imazamox,Immunohistochemistry,In situ hybridization |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayımlanan tam makale |
| Dergi Adı | TOXICOLOGY REPORTS |
| Dergi ISSN | 2214-7500 |
| Dergi Tarandığı Indeksler | ESCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2019 |
| Cilt No | 6 |
| Sayfalar | 42 / 50 |
| Doi Numarası | 10.1016/j.toxrep.2018.11.008 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S2214750018306875 |
| Atıf Sayıları | |
| WoS | 14 |
