An imazamox-based herbicide causes apoptotic changes in rat liver and pancreas
Yazarlar (10)
Doç. Dr. Çiğdem SEVİM Atatürk Üniversitesi, Türkiye
Doç. Dr. Selim Çomaklı Atatürk Üniversitesi, Türkiye
Doç. Dr. Ali Taghizadehghalehjoughi Atatürk Üniversitesi, Türkiye
Prof. Dr. Mustafa Özkaraca Atatürk Üniversitesi, Türkiye
Robin Mesnage King's College London, İngiltere
Leda Kovatsi
Aristotle University of Thessaloniki, Yunanistan
Aristotle University of Thessaloniki, Yunanistan
Tatyana I. Burykına
Sechenov First Moscow State Medical University, Rusya Federasyonu
Sechenov First Moscow State Medical University, Rusya Federasyonu
Alexandra Kalogerakı
University of Crete, Yunanistan
University of Crete, Yunanistan
Mıchael N. Antonıou King's College London, İngiltere
Arıstıdıs Tsatsakıs
University of Crete, Yunanistan
University of Crete, Yunanistan
| Makale Türü |
Özgün Makale
(SCOPUS dergilerinde yayınlanan tam makale)
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| Dergi Adı | Toxicology Reports | ||
| Dergi ISSN | 2214-7500 Dergi Bilgileri (2019) | ||
| Dergi Tarandığı Indeksler | Scopus | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2019 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-01-2019 |
| Cilt / Sayı / Sayfa | 6 / 1 / 42–50 | DOI | 10.1016/j.toxrep.2018.11.008 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S2214750018306875 | ||
| UAK Araştırma Alanları |
Tıbbi Farmakoloji
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| Özet |
| We studied the acute toxicity of an imazamox-based herbicide at 12, 24 and 36 mg/kg body (bw) weight imazamox equivalent dose on the liver and pancreatic tissue in Sprague Dawley rats. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, glucose, calcium as well as creatinine, were determined in blood samples, which were collected after 24, 48 and 72 h exposure. Caspase 3 and anti-insulin expression and immunopositivity were evaluated using in situ hybridization and immunohistochemistry, respectively. The imazamox-based herbicide evaluated in this study induced toxic effects even from the lowest dose tested (12 mg/kg bw). The two highest doses caused a statistically significant cytotoxicity on the Langerhans islet cells. Necrotic and degenerative changes were detected in hepatocytes at the two highest doses. Imazamox is considered to be poorly toxic to the liver … |
| Anahtar Kelimeler |
| Anti-insulin | Caspase 3 | Imazamox | Immunohistochemistry | In situ hybridization |
Science Direct
An imazamox-based herbicide causes apoptotic changes in rat liver and pancreas
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 25 |
| Scopus | 30 |
| Google Scholar | 40 |