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Acute glufosinate-based herbicide treatment in rats leads to increased ocular interleukin-1β and c-Fos protein levels, as well as intraocular pressure     
Yazarlar
Selim Çomaklı
Atatürk Üniversitesi, Türkiye
ÇOMAKLI SELİM
Atatürk Üniversitesi, Türkiye
Dr. Öğr. Üyesi Çiğdem SEVİM
Atatürk Üniversitesi, Türkiye
Dr. Öğr. Üyesi Çiğdem SEVİM
Atatürk Üniversitesi, Türkiye
George Kontadakıs
KONTADAKIS GEORGE
Doç. Dr. Elif DOĞAN
Atatürk Üniversitesi, Türkiye
Doç. Dr. Elif DOĞAN
Atatürk Üniversitesi, Türkiye
Ali Taghizadehghalehjoughi
TAGHİZADEHGHALEHJOUGHİ ALİ
Mustafa Özkaraca
Atatürk Üniversitesi, Türkiye
ÖZKARACA MUSTAFA
Atatürk Üniversitesi, Türkiye
Mıchael Aschner
ASCHNER MICHAEL
Taxıarchıs Konstantınos Nıkolouzakıs
NIKOLOUZAKIS TAXIARCHIS KONSTANTINOS
Arıstıdes Tsatsakıs
TSATSAKIS ARISTIDES
Özet
Glufosinate is a common herbicide with neurotoxic effects, leading to seizures, convulsions and memory loss. Glufosinate indirectly induces glutamate toxicity by inhibiting glutamine synthesis in astrocytes. Here, we studied the acute toxic effects of a glufosinate-based herbicide in rat optic nerve at three doses (40, 80 or 120 μM, equal to 714 or 21 mg/kg bw/day). Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, glucose, calcium, as well as creatinine concentrations were analyzed after 24, 48 and 72 h treatment. Intraocular pressure (IOP) (expressed as the average of both eyes) was measured with a rebound tonometer. Interleukin-1β (IL-1β) and c-Fos expression were determined by immunohistochemistry. The results established that the glufosinate-based herbicide significantly increased IL-1β and c-Fos immunopositivity in the optic nerve (p < 0.05), concomitant with increased IOP. These results suggest that commercial formulations of glufosinate acutely affect the optic nerve.
Anahtar Kelimeler
Glufosinate | Interleukin-1β | Intraocular pressure | c-fos
Makale Türü Özgün Makale
Makale Alt Türü ESCI dergilerinde yayımlanan tam makale
Dergi Adı TOXICOLOGY REPORTS
Dergi ISSN 2214-7500
Dergi Tarandığı Indeksler ESCI
Makale Dili İngilizce
Basım Tarihi 01-2019
Cilt No 6
Sayfalar 155 / 160
Doi Numarası 10.1016/j.toxrep.2019.01.004
Makale Linki https://linkinghub.elsevier.com/retrieve/pii/S2214750018307819