Cadmium sulfide-induced toxicity in the cortex and cerebellum: In vitro and in vivo studies
Yazarlar (12)
Atefeh Varmazyari
Ali Taghizadehghalehjoughi
Doç. Dr. Çiğdem SEVİM Atatürk Üniversitesi, Türkiye
Prof. Dr. Özlem Barış Atatürk Üniversitesi, Türkiye
Dr. Öğr. Üyesi Gizem Eser Iğdır Üniversitesi, Türkiye
Prof. Dr. Serkan Yıldırım Atatürk Üniversitesi, Türkiye
Prof. Dr. Ahmet Hacımüftüoğlu Atatürk Üniversitesi, Türkiye
Alexandra Buha
Davıd R. Wallace
Arıstıdıs Tsatsakıs
Mıchael Aschner
Yaroslav Mezhuev
| Makale Türü | Özgün Makale (SCOPUS dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | TOXICOLOGY REPORTS | ||
| Dergi ISSN | 2214-7500 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | Scopus | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2020 |
| Cilt / Sayı / Sayfa | 7 / 0 / 637–648 | DOI | 10.1016/j.toxrep.2020.04.011 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S2214750019304202 | ||
| UAK Araştırma Alanları |
Tıbbi Farmakoloji
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| Özet |
| Living organisms have an innate ability to regulate the synthesis of inorganic materials, such as bones and teeth in humans. Cadmium sulfide (CdS) can be utilized as a quantum dot that functions as a unique light-emitting semiconductor nanocrystal. The increased use in CdS has led to an increased inhalation and ingestion rate of CdS by humans which requires a broader appreciation for the acute and chronic toxicity of CdS. We investigated the toxic effects of CdS on cerebellar cell cultures and rat brain. We employed a 'green synthesis' biosynthesis process to obtain biocompatible material that can be used in living organisms, such as K64. Nanocrystal formation was initiated by adding CdCl (1 mM) to the cell cultures. Our results established that increased concentrations of CdS (0.1 μg/mL) lead to decreased cell viability as assessed using 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT), total antioxidant capacity (TAC), and total oxidant status (TOS). The studies showed that exposure to CdS (1 mg/kg) glial fibrillary acidic protein (GFAP) and 8-hydroxy-2' -deoxyguanosine (8-OHdG) were increased. Collectively, we describe a model system that addresses the process from the synthesis to the neurotoxicity assessment for CdS both and . These data will be beneficial in establishing a more comprehensive pathway for the understanding of quantum dot-induced neurotoxicity. |
| Anahtar Kelimeler |
| CdS | Cerebellum neuron | Green synthesis | Neurotoxicity | Quantum dots |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 47 |