Effects of high fructose diet on lipid metabolism and the hepatic NF-κB/ SIRT-1 pathway
Yazarlar (7)
Prof. Dr. Hatice İskender Artvin Çoruh Üniversitesi, Türkiye
Prof. Dr. Güler Yenice Atatürk Üniversitesi, Türkiye
Prof. Dr. Kübra Asena Terim Kapakin Atatürk Üniversitesi, Türkiye
Prof. Dr. Eda Dokumacıoğlu Artvin Çoruh Üniversitesi, Türkiye
Doç. Dr. Çiğdem SEVİM Kastamonu Üniversitesi, Türkiye
Armağan Hayırlı
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Prof. Dr. Serdar Altun Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | BIOTECHNIC & HISTOCHEMISTRY (Q4) | ||
| Dergi ISSN | 1052-0295 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2022 |
| Cilt / Sayı / Sayfa | 97 / 1 / 30–38 | DOI | 10.1080/10520295.2021.1890214 |
| Makale Linki | http://dx.doi.org/10.1080/10520295.2021.1890214 | ||
| UAK Araştırma Alanları |
Tıbbi Farmakoloji
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| Özet |
| The liver is the primary site for fructose metabolism; therefore, the liver is susceptible to fructose related metabolic disturbances including metabolic insulin dysfunction, dyslipidemia and inflammation. We investigated whether astaxanthin (ASX) can modify hepatic nuclear factor-kappa B (NF-κB)/sirtuin-1 (SIRT-1) expression to alter oxidative stress caused by ingestion of excess fructose in rats. The animals were divided randomly into two x two factorially arranged groups: two regimens were given either water (W) or 30% fructose in drinking water (F). These two groups were divided further into two subgroups each: two treatments, either orally with 0.2 ml olive oil (OO) or 1 mg ASX/kg/day in 0.2 ml olive oil (ASX). Fructose administration increased serum glucose, triglycerides and very low density lipoproteins, and decreased serum concentration of high density lipoproteins; fructose did not alter serum total cholesterol. Excess fructose decreased hepatic superoxide dismutase (SOD) and increased hepatic NF-κB and MDA levels. ASX treatment increased hepatic SIRT-1 and decreased hepatic NF-κB and malondialdehyde (MDA) levels. ASX treatment decreased hepatic NF-κB and increased SOD levels, but did not alter MDA level in rats fed high fructose. ASX administration ameliorated oxidative stress caused by excess fructose by increasing hepatic NF-κB and SIRT-1 expression. |
| Anahtar Kelimeler |
| Astaxanthin | NF–κB | SIRT–1 | fructose | lipid | liver | metabolism | oxidative stress | rats |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 14 |