| Yazarlar |
Hatice İskender
Artvin Çoruh Üniversitesi, Türkiye |
|
Güler Yenice
Atatürk Üniversitesi, Türkiye |
|
Kübra Asena Terim Kapakin
Atatürk Üniversitesi, Türkiye |
|
Eda Dokumacıoğlu
Artvin Çoruh Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Çiğdem SEVİM
Kastamonu Üniversitesi, Türkiye |
|
Armağan Hayırlı
Atatürk Üniversitesi, Türkiye |
|
Serdar Altun
Türkiye |
| Özet |
| The liver is the primary site for fructose metabolism; therefore, the liver is susceptible to fructose related metabolic disturbances including metabolic insulin dysfunction, dyslipidemia and inflammation. We investigated whether astaxanthin (ASX) can modify hepatic nuclear factor-kappa B (NF-κB)/sirtuin-1 (SIRT-1) expression to alter oxidative stress caused by ingestion of excess fructose in rats. The animals were divided randomly into two x two factorially arranged groups: two regimens were given either water (W) or 30% fructose in drinking water (F). These two groups were divided further into two subgroups each: two treatments, either orally with 0.2 ml olive oil (OO) or 1 mg ASX/kg/day in 0.2 ml olive oil (ASX). Fructose administration increased serum glucose, triglycerides and very low density lipoproteins, and decreased serum concentration of high density lipoproteins; fructose did not alter serum total cholesterol. Excess fructose decreased hepatic superoxide dismutase (SOD) and increased hepatic NF-κB and MDA levels. ASX treatment increased hepatic SIRT-1 and decreased hepatic NF-κB and malondialdehyde (MDA) levels. ASX treatment decreased hepatic NF-κB and increased SOD levels, but did not alter MDA level in rats fed high fructose. ASX administration ameliorated oxidative stress caused by excess fructose by increasing hepatic NF-κB and SIRT-1 expression. |
| Anahtar Kelimeler |
| Astaxanthin | NF–κB | SIRT–1 | fructose | lipid | liver | metabolism | oxidative stress | rats |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | BIOTECHNIC & HISTOCHEMISTRY |
| Dergi ISSN | 1052-0295 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2022 |
| Cilt No | 97 |
| Sayı | 1 |
| Sayfalar | 30 / 38 |
| Doi Numarası | 10.1080/10520295.2021.1890214 |
| Makale Linki | http://dx.doi.org/10.1080/10520295.2021.1890214 |
| Atıf Sayıları | |
| WoS | 7 |
