Apoptosis is induced by sub-acute exposure to 3-MCPD and glycidol on Wistar Albino rat brain cells
Yazarlar (7)
Doç. Dr. Çiğdem SEVİM Kastamonu Üniversitesi, Türkiye
Prof. Dr. Mustafa Özkaraca Türkiye
Doç. Dr. Mehtap Kara Türkiye
Dr. Öğr. Üyesi Nergis Ulaş Türkiye
Ali Sefa Mendil
Denısa Margına
Arıstıdıs Tsatsakıs
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (Q1) | ||
| Dergi ISSN | 1382-6689 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2021 |
| Cilt / Sayı / Sayfa | 87 / 0 / 1–6 | DOI | 10.1016/j.etap.2021.103735 |
| Makale Linki | https://doi.org/10.1016/j.etap.2021.103735 | ||
| UAK Araştırma Alanları |
Tıbbi Farmakoloji
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| Özet |
| 3-chloropropane-1,2-diol (3-MCPD) and its toxic metabolite glycidol were classified by the International Agency for Research on Cancer (IARC) as belonging to group 2B and 2A for humans. This study aimed to determine the sub-acute toxicity of these agents. Rats were exposed to 3-MCPD at 0.87 and 10 mg/kg/bw and glycidol (2,4 and 37,5 mg/kg/bw) for 90 days. miR-21 gene expression levels significantly decreased in all group's cerebellar tissues compared with control. Exposure to 10 mg/kg/bw 3-MCPD showed significant increases in PTEN in brain as compared to control group. The Akt gen expressions were significantly decreased in 3-MCPD and glycidol groups when compared to control group brains. Additionally, Caspase 3 and AIF immunopositivity significantly increased in 3-MCPD high dose and glycidol high dose groups in cerebellum granular layers compared to control. The results of the present study conclude that 3-MCPD and glycidol can induce apoptosis in rat brain tissue. |
| Anahtar Kelimeler |
| 3-MCPD | Glycidol | PTEN-Akt pathway | miR-21 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 17 |