Apoptosis is induced by sub-acute exposure to 3-MCPD and glycidol on Wistar Albino rat brain cells
Yazarlar (7)
Doç. Dr. Çiğdem SEVİM Kastamonu Üniversitesi, Türkiye
Prof. Dr. Mustafa Özkaraca Cumhuriyet Üniversitesi, Türkiye
Doç. Dr. Mehtap Kara Istanbul Üniversitesi, Türkiye
Dr. Öğr. Üyesi Nergis Ulaş Atatürk Üniversitesi, Türkiye
Ali Sefa Mendil
Erciyes Üniversitesi, Türkiye
Erciyes Üniversitesi, Türkiye
Denısa Margına
Universitatea De Medicina Si Farmacie Carol Davila Din Bucuresti, Romanya
Universitatea De Medicina Si Farmacie Carol Davila Din Bucuresti, Romanya
Arıstıdıs Tsatsakıs
University of Crete, Yunanistan
University of Crete, Yunanistan
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Environmental Toxicology and Pharmacology (Q1) | ||
| Dergi ISSN | 1382-6689 Dergi Bilgileri (2021) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2021 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-10-2021 |
| Cilt / Sayı / Sayfa | 87 / 1 / 1–6 | DOI | 10.1016/j.etap.2021.103735 |
| Makale Linki | https://doi.org/10.1016/j.etap.2021.103735 | ||
| UAK Araştırma Alanları |
Tıbbi Farmakoloji
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| Özet |
| 3-chloropropane-1,2-diol (3-MCPD) and its toxic metabolite glycidol were classified by the International Agency for Research on Cancer (IARC) as belonging to group 2B and 2A for humans. This study aimed to determine the sub-acute toxicity of these agents. Rats were exposed to 3-MCPD at 0.87 and 10 mg/kg/bw and glycidol (2,4 and 37,5 mg/kg/bw) for 90 days. miR-21 gene expression levels significantly decreased in all group’s cerebellar tissues compared with control. Exposure to 10 mg/kg/bw 3-MCPD showed significant increases in PTEN in brain as compared to control group. The Akt gen expressions were significantly decreased in 3-MCPD and glycidol groups when compared to control group brains. Additionally, Caspase 3 and AIF immunopositivity significantly increased in 3-MCPD high dose and glycidol high dose groups in cerebellum granular layers compared to control. The results of the present … |
| Anahtar Kelimeler |
| 3-MCPD | Glycidol | miR-21 | PTEN-Akt pathway |
Science Direct
Apoptosis is induced by sub-acute exposure to 3-MCPD and glycidol on Wistar Albino rat brain cells
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 17 |
| Scopus | 21 |
| Google Scholar | 28 |