The sesquiterpenoid valerenic acid protects neuronal cells from the detrimental effects of the fungicide benomyl on apoptosis and DNA oxidation
 
Yazarlar (8)
Doç. Dr. Mehtap Kara İstanbul Üniversitesi, Türkiye
Doç. Dr. Ezgi Öztaş Türkiye
Tuğçe Boran Türkiye
Doç. Dr. Çiğdem SEVİM Kastamonu Üniversitesi, Türkiye
Seda Eren Keskin Türkiye
Arıstıdıs S Veskoukıs
Sergeı V Kuzmın
Arıstıdes M Tsatsakıs
Makale Türü Açık Erişim Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı HUMAN & EXPERIMENTAL TOXICOLOGY (Q2)
Dergi ISSN 0960-3271 Dergi Bilgileri (2022)
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 05-2022
Kabul Tarihi – Yayınlanma Tarihi 01-01-2022
Cilt / Sayı / Sayfa 41 / 0 / 1–10 DOI 10.1177/09603271221101038
Makale Linki http://dx.doi.org/10.1177/09603271221101038
UAK Araştırma Alanları
Tıbbi Farmakoloji
Özet
Background Valerenic acid (VA), a sesquiterpenoid of the plant Valeriana officinalis, has attracted attention of the research community due to its potential positive role against neurodegenerative diseases induced by chemicals. However, the relevant evidence in the literature is scarce. Therefore, this study aimed to examine the putative protective role of VA on the toxic effects of the fungicide benomyl on SH-SY5Y neural cells. Methods Cell viability was determined via the MTT and NRU assays, DNA damage was assessed via comet assay and apoptosis was evaluated through the expression of relevant genes. Results According to the results, exposure of the cells to benomyl enhanced viability inhibition and promoted DNA damage and apoptosis since the expression levels of the genes coding for MAPK8, NF-kB, Bax, Caspase-9 and Caspase-3 were increased. Treatment of the cells with VA ameliorated these effects in a concentration dependent manner. Conclusion It is concluded that the molecular mechanism through which benomyl exerts its toxic action appears to depend on DNA oxidation and apoptosis induction. Furthermore, VA, a plant-derived compound is a protective antioxidant against pesticide-induced toxicity. Therefore, herbs, extracts and compounds of plant origin could be used as nutritional supplements that back up the beneficial role of medicine in neurodegenerative diseases.
Anahtar Kelimeler
DNA damage | Valerenic acid | apoptosis | benomyl | oxidative stress | redox-related mechanism
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Web of Science 3
The sesquiterpenoid valerenic acid protects neuronal cells from the detrimental effects of the fungicide benomyl on apoptosis and DNA oxidation

Paylaş

İletişim
  • Kastamonu Üniversitesi Rektörlüğü, Kuzeykent Kampüsü, Merkez/Kastamonu
  • unis@kastamonu.edu.tr 03662801000
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