Investigation of the anti-inflammatory effects of caffeic acid phenethyl ester in a model of λ-Carrageenan–induced paw edema in rats
Yazarlar (5)
Halil Sezgin Semis Private Buhara Hospital, Türkiye
Cihan Gur Atatürk Üniversitesi, Türkiye
Mustafa Ileriturk Atatürk Üniversitesi, Türkiye
Prof. Dr. Özgür KAYNAR Kastamonu Üniversitesi, Türkiye
Fatih Mehmet Kandemir Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Human and Experimental Toxicology (Q3) | ||
| Dergi ISSN | 0960-3271 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2021 |
| Cilt / Sayı / Sayfa | 40 / 12 / – | DOI | 10.1177/09603271211054436 |
| Makale Linki | http://dx.doi.org/10.1177/09603271211054436 | ||
| Özet |
| In the present study, it is aimed to evaluate the effects of caffeic acid phenethyl ester (CAPE) against acute paw inflammation induced by carragenan (Carr) at macro and micro levels. Therefore, in this study, 1 hour after administering intraperitoneal of indomethacin (Ind) or CAPE (10 and 30 mg/kg body weight) to Sprague Dawley rats, Carr was injected intraplantarly into their right paws. The paw volumes of the rats were measured with a plethysmometer until the 4th hour. Also, X-ray and thermal camera images were taken to determine edema and temperature changes. At the end of the study, after the paw tissues and serums were taken, oxidative stress and inflammation status were determined using biochemical, molecular, and western blot techniques. In addition, lipid and protein profiles in paw tissue were determined using HPTLC and electrophoresis methods. The results depicted that a high dose of CAPE against Carr-induced inflammation may be almost as effective as Ind used as reference. |
| Anahtar Kelimeler |
| caffeic acid phenethyl ester | cyclooxygenase-2 | inflammation | paw edema | λ-Carrageenan |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 54 |
| Scopus | 60 |