The Humoral Immun Response of Mice to Liposomes Containing Brucella melitensis Outer Membrane Fragments
Yazarlar (7)
Fatma Kaynak Onurdag Gazi Üniversitesi, Türkiye
Tuncer Degim Gazi Üniversitesi, Türkiye
Zelihagul Deǧim Gazi Üniversitesi, Türkiye
Ismail Kutlu Refik Saydam Hıfzıssıhha Merkezi Başkanlığ - Ana Sayfa, Türkiye
Prof. Dr. Özgür KAYNAR Atatürk Üniversitesi, Türkiye
Gulsen Gunes Inönü Üniversitesi, Türkiye
Ufuk Abbasoglu Gazi Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Animal and Veterinary Advances | ||
| Dergi ISSN | 1680-5593 | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2008 |
| Cilt / Sayı / Sayfa | 7 / 8 / 991–995 | DOI | – |
| Özet |
| Brucellosis is an important zoonotic disease and the prevention is made by vaccination of animals. For ewes Brucella melitensis REV-1 live attenuated vaccine is widely used but because of some risks such as being infected during the vaccination, re-infection of animals, a new vaccine with less side effect is need to be improved. In this study it was aimed to determine a strong humoral immune response by encapsulating the Brucella outer membrane antigens with the optimum liposome formulation and the statistical analyses showed that the Brucella outer membrane extract encapsulated with liposome can evoke humoral immune response better than live attenuated B. melitensis REV-1 vaccine in mice. © Medwell Journals, 2008. |
| Anahtar Kelimeler |
| Brucella | Humoral immunity | Liposomes | Vaccine |
