| Yazarlar |
Fatma Kaynak Onurdağ
Trakya Üniversitesi, Türkiye |
|
İsmail Tuncer Değim
Gazi Üniversitesi, Türkiye |
|
Zelihagül Değim
Gazi Üniversitesi, Türkiye |
|
Kutlu İsmail
|
Prof. Dr. Özgür KAYNAR
Atatürk Üniversitesi, Türkiye |
|
Gülsen Güneş
İnönü Üniversitesi, Türkiye |
|
Ufuk Abbasoğlu
Gazi Üniversitesi, Türkiye |
| Özet |
| Brucellosis is an important zoonotic disease and the prevention is made by vaccination of animals. For ewes Brucella melitensis REV-1 live attenuated vaccine is widely used but because of some risks such as being infected during the vaccination, re-infection of animals, a new vaccine with less side effect is need to be improved. In this study it was aimed to determine a strong humoral immune response by encapsulating the Brucella outer membrane antigens with the optimum liposome formulation and the statistical analyses showed that the Brucella outer membrane extract encapsulated with liposome can evoke humoral immune response better than live attenuated B. melitensis REV-1 vaccine in mice. © Medwell Journals, 2008. |
| Anahtar Kelimeler |
| Brucella | Humoral immunity | Liposomes | Vaccine |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF ANIMAL AND VETERINARY ADVANCES |
| Dergi ISSN | 1680-5593 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2008 |
| Cilt No | 7 |
| Sayı | 8 |
| Sayfalar | 991 / 995 |
