| Yazarlar |
Tolga Karapınar
Fırat Üniversitesi, Türkiye |
|
Yesari Eröksüz
Fırat Üniversitesi, Türkiye |
|
Armağan Hayırlı
Atatürk Üniversitesi, Türkiye |
|
Enver Beytut
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Özgür KAYNAR
Atatürk Üniversitesi, Türkiye |
|
Ersoy Baydar
Balıkesir Üniversitesi, Türkiye |
|
İbrahim Sözdutmaz
Erciyes Üniversitesi, Türkiye |
|
Hakan Işıdan
Cumhuriyet Üniversitesi, Türkiye |
| Özet |
| Background: Cardiac troponin I (cTnI) is a peripheral blood marker for myocardial damage. Because of the unavailability of goat-specific cTnI assays human cTnI assays may be validated for detection of myocarditis in goat kids. Objectives: The purpose of the study was to evaluate 2 commercially available human cTnI assays in goat kids with myocardial damage, and to determine the cTnI expression in cardiac muscle. Materials and Methods: Plasma cTnI concentrations were measured in healthy goat kids (n = 7) and goat kids with myocardial damage (n = 8) using the Beckman Coulter Access Accu TnI and the Biomérieux Vidas Ultra. The results were correlated with gross necropsy and histopathologic findings, and cTnI immunhistochemistry in cardiac tissue. Results: Macro- and microscopic findings confirmed myocardial damage in the myocarditis group. Mean plasma cTnI concentration was significantly higher in the myocarditis group than in the healthy control group (104.82 vs 0.02 ng/mL). The overall mean plasma cTnI concentration measured by Biomérieux Vidas Ultra (61.75 ng/mL, 95% CI: 19.55-103.95) was comparable to the mean measured by Beckman Coulter Access Accu TnI (50.08 ng/mL, 95% CI: 24.11-76.06), and cTnI concentrations measured by these assays were highly correlated (r = .977) with a -6.2% bias. Both assays were precise and accurate. Conclusion: The human-specific Beckman Coulter Access Accu TnI and the Biomérieux Vidas Ultra can be used for diagnostic confirmation of myocardial damage in caprine medicine. |
| Anahtar Kelimeler |
| Biomarker,cTnI,goat,myocardial damage |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Veterinary Clinical Pathology |
| Dergi ISSN | 0275-6382 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2016 |
| Cilt No | 45 |
| Sayı | 1 |
| Sayfalar | 1 / 8 |
| Doi Numarası | 10.1111/vcp.12328 |
| Makale Linki | http://doi.wiley.com/10.1111/vcp.12328 |
| Atıf Sayıları | |
| WoS | 6 |
| SCOPUS | 6 |
