| Yazarlar |
Arzu Şahin
Ordu Üniversitesi, Türkiye |
|
Hatice İskender
Artvin Çoruh Üniversitesi, Türkiye |
|
Kübra Asena Terim Kapakin
Atatürk Üniversitesi, Türkiye |
|
Konca Altınkaynak
Sağlık Bilimleri Üniversitesi, Türkiye |
|
Armağan Hayırlı
Atatürk Üniversitesi, Türkiye |
|
Aylin Gönültaş
|
Prof. Dr. Özgür KAYNAR
Atatürk Üniversitesi, Türkiye |
| Özet |
| Lead (Pb) is a heavy metal, which adversely affects thyroid gland function and structure. Due to its high molecular weight and abundant functional groups, humic acid substances (HAS) can form chelates with heavy metals. The experiment was conducted to evaluate the prophylactic effect of HAS on thyroid hormone levels and histopathological lesions of laying hens exposed to lead (Pb) poisoning. After a week of adaptation, 192 Lohmann White laying hens (25 weeks of age) were fed one of four diets: a basal diet (BD) or the BD with HAS (0.15%), with Pb (0.3 g/kg), or with both. Experimental groups were replicated in 12 cages, with four hens each. Pb poisoning did not alter triiodothyronine (FT3; 3.22 ± 0.20 ng/dL) or thyroxine (FT4; 0.71 ± 0.08 ng/dL) concentrations, but caused a 167% increase in thyroid stimulating hormone (TSH) concentration. HAS supplementation returned the high TSH levels of hens exposed to Pb poisoning to normal values. Degenerative changes in the epithelial cells of the thyroid gland of the hens exposed to Pb poisoning were evidenced. Connective tissue cells in the interfollicular area and total amount of colloids with partially atrophic follicles were observed. These histopathological findings were less severe when HAS was added to the diet. In conclusion, HAS alleviates the effects of Pb poisoning on thyroid gland function and structure, possibly preventing its internalization by the tissue by forming chelates and exerting antiinflammatory effects. |
| Anahtar Kelimeler |
| Chicken | Humic acid substances | Lead poisoning | Thyroid gland |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Brazilian Journal of Poultry Science |
| Dergi ISSN | 1516-635X |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2016 |
| Cilt No | 18 |
| Sayı | 4 |
| Sayfalar | 1 / 8 |
| Doi Numarası | 10.1590/1806-9061-2016-0266 |
| Atıf Sayıları | |
| SCOPUS | 14 |
