The Effect of Humic Acid Substances on the Thyroid Function and Structure in Lead Poisoning
Yazarlar (7)
A. Sahin
Ordu Üniversitesi, Türkiye
Prof. Dr. Hatice Iskender Artvin Coruh University, Türkiye
K. A. Terim Kapakin
Atatürk Üniversitesi, Türkiye
K. Altinkaynak
Regional Training And Research Hospital, Türkiye
A. Hayirli
Atatürk Üniversitesi, Türkiye
A. Gonultas
Tekirdag State Hospital, Türkiye
Prof. Dr. Özgür KAYNAR Atatürk Üniversitesi, Türkiye
Makale Türü Açık Erişim Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Revista Brasileira De Ciencia Avicola Brazilian Journal of Poultry Science (Q3)
Dergi ISSN 1516-635X Dergi Bilgileri (2016)
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 12-2016
Kabul Tarihi – Yayınlanma Tarihi 01-12-2016
Cilt / Sayı / Sayfa 18 / 4 / 649–654 DOI 10.1590/1806-9061-2016-0299
Makale Linki http://www.scielo.br/pdf/rbca/v18n4/1516-635X-rbca-18-04-00649.pdf
UAK Araştırma Alanları
Veteriner Biyokimyası
Özet
Lead (Pb) is a heavy metal, which adversely affects thyroid gland function and structure. Due to its high molecular weight and abundant functional groups, humic acid substances (HAS) can form chelates with heavy metals. The experiment was conducted to evaluate the prophylactic effect of HAS on thyroid hormone levels and histopathological lesions of laying hens exposed to lead (Pb) poisoning. After a week of adaptation, 192 Lohmann White laying hens (25 weeks of age) were fed one of four diets: a basal diet (BD) or the BD with HAS (0.15%), with Pb (0.3 g/kg), or with both. Experimental groups were replicated in 12 cages, with four hens each. Pb poisoning did not alter triiodothyronine (FT3; 3.22 ± 0.20 ng/dL) or thyroxine (FT4; 0.71 ± 0.08 ng/dL) concentrations, but caused a 167% increase in thyroid stimulating hormone (TSH) concentration. HAS supplementation returned the high TSH levels of hens exposed to Pb poisoning to normal values. Degenerative changes in the epithelial cells of the thyroid gland of the hens exposed to Pb poisoning were evidenced. Connective tissue cells in the interfollicular area and total amount of colloids with partially atrophic follicles were observed. These histopathological findings were less severe when HAS was added to the diet. In conclusion, HAS alleviates the effects of Pb poisoning on thyroid gland function and structure, possibly preventing its internalization by the tissue by forming chelates and exerting antiinflammatory effects.
Anahtar Kelimeler
Chicken | Humic acid substances | Lead poisoning | Thyroid gland
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BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Scopus 15
The Effect of Humic Acid Substances on the Thyroid Function and Structure in Lead Poisoning

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  • Kastamonu Üniversitesi Rektörlüğü, Kuzeykent Kampüsü, Merkez/Kastamonu
  • unis@kastamonu.edu.tr 03662801000
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