| Yazarlar |
Tolga Karapınar
Fırat Üniversitesi, Türkiye |
Prof. Dr. Özgür KAYNAR
Atatürk Üniversitesi, Türkiye |
|
Armağan Hayırlı
Atatürk Üniversitesi, Türkiye |
|
Mustafa Köm
Fırat Üniversitesi, Türkiye |
| Özet |
| Background: Despite being used commonly in bovine medicine, information on reliability of point-of-care (POC) lactate meters is limited. Objective: To determine the validity of 4 commercially available POC lactate meters in cattle. Animals: Cattle with various diseases (n = 120). Methods: Blood samples collected from the jugular vein were processed immediately on POC lactate meters. Plasma l-lactate concentration was measured by the enzymatic-colorimetric method (ELISA). Data were subjected to Friedman's test for comparison, Passing-Bablok regression and Bland-Altman plot analyses for reliability, and receiver operating characteristics analysis for sensitivity (Se) and specificity (Sp). Results: The POC lactate meters were highly correlated with ELISA (r = 0.98-0.99) despite disagreements among units. When regressed on ELISA, blood l-lactate concentrations generated from Accutrend Plus and Lactate Pro were linear up to 16.6 and 15.7 mmol/L, respectively, whereas those generated from i-STAT and Lactate Scout were linear up to 19.5 and 19.7 mmol/L, respectively. All POC lactate meters had a Se of 100% with Sp of 95.7-98.6% at a plasma l-lactate cut-off concentration of 4 mmol/L. i-STAT had the best accuracy (99.0%) and precision (99.8%), the best linear fit (y = -0.13 + 1.04X) yielding the lowest bias (-6.6%) as well as the highest Se (100%) and Sp (98.6%). Conclusions and Clinical Importance: Despite high correlation with the reference method, dilution is needed for Accutrend Plus/Lactate Pro and i-STAT/Lactate Scout if concentrations >15 and 20 mmol/L, respectively. i-STAT provided the most accurate and precise results. © 2013 by the American College of Veterinary Internal Medicine. |
| Anahtar Kelimeler |
| Accuracy,Bovine,Portable lactate meter,Precision,Sensitivity,Specificity |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Veterinary Internal Medicine |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2013 |
| Cilt No | 27 |
| Sayı | 6 |
| Sayfalar | 1596 / 1603 |
| Doi Numarası | 10.1111/jvim.12204 |
| Makale Linki | http://onlinelibrary.wiley.com/doi/10.1111/jvim.12204/epdf |
| Atıf Sayıları | |
| WoS | 24 |
| SCOPUS | 27 |
