Pharmacokinetics and Penetration into the Aqueous Humor of Long Action Oxytetracycline after Single Dose Intravenous and Intramuscular Administrations in Rabbits
Yazarlar (5)
Prof. Dr. Feride Koç Erciyes Üniversitesi, Türkiye
Prof. Dr. Özgür KAYNAR Atatürk Üniversitesi, Türkiye
Zafer Okumuş
Atatürk Üniversitesi, Türkiye
Prof. Dr. Elif DOĞAN Atatürk Üniversitesi, Türkiye
Prof. Dr. Latif Emrah Yanmaz Atatürk Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Journal of Animal and Veterinary Advances (Q4)
Dergi ISSN 1680-5593 Dergi Bilgileri (2009)
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 10-2009
Cilt / Sayı / Sayfa 8 / 10 / 1900–1905 DOI –
Makale Linki http://docsdrive.com/pdfs/medwelljournals/javaa/2009/1900-1905.pdf
UAK Araştırma Alanları
Veteriner Biyokimyası
Özet
The aim of this study was to investigate pharmacokinetics and penetration into the aqueous humor of Long Action Oxytetracycline (OTC-LA) after Intravenous (IV) and Intramuscular (IM) administrations, at a single dose of 20 mg kg-1 b.wt in rabbits. After administrations of the long action formulation, the plasma oxytetracycline concentrations were evaluated using a two-compartmental open model. The study was designed according to a two-period cross-over and the plasma OTC concentration was measured using the ELISA procedure. The elimination half-lives (t1/2β) of the OTC-LA after IV and IM administrations were 12.60±0.92 and 38.67±4.40 h, respectively. After IV administration, the volume of distribution (Vdss) and total body Clearance (Cltot) values of the drug were 3.42±0.21 L kg-1 and 0.19±0.01 L/h/kg, respectively. The maximum concentration of the drug (Cmax) in the plasma (4.23±0.43 μg mL-1) was achieved at 2.0 h (tmax) after IM administration. The Minimum therapeutic plasma Concentration (MIC) of the drug at the amount >0.5 μg mL-1 was maintained until 48 h after IV and IM administrations. The intramuscular bioavailabihty of the drug was 0.79±0.10%. After IV and IM administrations of OTC-LA formulation, the maximum concentrations of the drug in the aqueous humor were 0.1 and 0.068 μg mL-1, respectively. However, the concentrations of the drug in the aqueous humor were below the MIC value (0.5 μgmL-1) during 12-72 and 4-48 h for IM and IV administrations, respectively. © Medwell Journals, 2009.
Anahtar Kelimeler
Aqueous humor | Intravenous | Oxytetracycline | Pharmacokinetics | Plasma | Rabbit
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları

Paylaş

İletişim
  • Kastamonu Üniversitesi Rektörlüğü, Kuzeykent Kampüsü, Merkez/Kastamonu
  • unis@kastamonu.edu.tr 03662801000
Sosyal Media
Talentsoft Yazılım Talent Yazılım
Tasarım ve Programlama #2025