Bovine respiratory disease in naturally infected calves clinical signs blood gases and cytokine response

Ozkanlar, Y.; Aktas, M. S.; KAYNAR, Özgür; Ozkanlar, S.; Kirecci, E.; Yildiz, L.

Bovine respiratory disease in naturally infected calves clinical signs blood gases and cytokine response

Yazarlar (6)

Y. Ozkanlar Atatürk Üniversitesi, Türkiye

M. S. Aktas Atatürk Üniversitesi, Türkiye

Prof. Dr. Özgür KAYNAR Atatürk Üniversitesi, Türkiye

S. Ozkanlar Atatürk Üniversitesi, Türkiye

E. Kirecci University K. Maras, Türkiye

L. Yildiz Ataturk University, Faculty Of Medicine, Türkiye

Makale Türü	Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı	Revue De Medecine Veterinaire
Dergi ISSN	0035-1555 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler	SCI-Expanded
Makale Dili	İngilizce	Basım Tarihi	03-2012
Cilt / Sayı / Sayfa	163 / 3 / 123–130	DOI	–

Özet

Viral and bacterial aetiology, clinical symptoms, venous blood gases and cytokine production were aimed to investigate in naturally infected calves with bovine respiratory disease (BRD). Nasal swap and bronchoalveolar lavage samples and blood samples were obtained from 10 healthy control calves and from 48 calves with respiratory symptoms from 12 different herds and exposed to predisposing factors (insufficient aeration and hygiene) (BRD group) before tulathromycin and carprofen treatment. Virus isolations were achieved in 25% of the swap samples: BVDV (bovine viral diarrhoea virus), BRSV (bovine respiratory syncytial virus) and IBRV (infectious bovine rhinotracheitis virus) were identified in 12.5%, 8.3% and 6.2% of diseased calves respectively. Serum anti-BVDV antibodies were also detected in 68.75% of BRD calves using a sero-neutralization test. Lungs from all virally (directly and indirectly) infected calves were also invaded with bacteria (in majority with Mannheimia hemolytica, and P. multocida, α-haemolytic Streptococcus and coagulase negative Staphylococcus, at a lesser extend). The prevalence of the total bacterial infections was 100% and poly-infections were also frequent (47.92%). Respiration rate and rectal temperature were significantly increased (P < 0.001) in the affected calves. Nasal and ocular discharge, cough and dyspnoea were additional clinical findings. Venous gas analysis revealed the occurrence of a respiratory acidosis (decrease in blood pH coupled to increase in pCO 2 and decrease in pO 2) in diseased calves that was positively correlated with the respiratory frequency. Furthermore, serum concentrations of tumour necrosis factor-α and interleukin-6 were detected to be significantly high only in newly affected calves. Tulathromycin and carprofen treatment induced clinical recovery after 15 days and 30 days in 91.6% and 95.83% respectively of diseased calves. As a result, blood gases, respiratory rate, rectal temperature and respiratory signs have been deteriorated in these calves. A respiratory acidosis and an early inflammatory cytokine production occur during BRD, mainly related to the BVDV and M. heamolytica as most common agents involved in the disease.

Anahtar Kelimeler

BM Sürdürülebilir Kalkınma Amaçları

Atıf Sayıları
Scopus	25

Dergi Adı	REVUE DE MEDECINE VETERINAIRE
Yayıncı	Ecole Nationale Veterinaire
Açık Erişim	Hayır
ISSN	0035-1555
E-ISSN	2258-0646
CiteScore	1,3
SJR	0,207
SNIP	0,977

Bovine respiratory disease in naturally infected calves clinical signs blood gases and cytokine response

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