| Yazarlar |
Günay Kozan
Türkiye |
|
Bülent Aktan
Atatürk Üniversitesi, Türkiye |
|
Muhammed Sedat Sakat
Atatürk Üniversitesi, Türkiye |
|
Sezgin Kurt
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Fatih ÖNER
Kastamonu Üniversitesi, Türkiye |
|
Adem Kara
Atatürk Üniversitesi, Türkiye |
| Özet |
| The results of the study showed that clarithromycin has anti-inflammatory and antioxidant effects and, when it is combined with prednisolone, those effects gain strength. The present study aims to investigate the effects that the antioxidant and anti-inflammatory activities of clarithromycin and/or prednisolone have on experimental otitis media in effusion-induced guinea-pigs. In this study, 35-male guinea pigs were randomly divided into five-groups. For the experimental otitis media, intra-tympanic histamine (0.1 ml) was injected into the guinea pigs in all of the groups except the control group. Then, 24-h after the intra-tympanic injections, clarithromycin (15 mg/kg/day) and/or prednisolone (1 mg/kg/day) were applied intraperitoneally to the guinea-pigs for 7-days. The biochemical analysis showed an increase in antioxidant capacity and a decrease in oxidant status and malondialdehyde (MDA) levels in the clarithromycin group and the prednisolone group and especially in the clarithromycin+prednisolone group, as compared to the experimental group (p < 0.05). In the cytokine analysis, lower levels of interleukin (IL)-6 and IL-17A and higher IL-10 were found in the clarithromycin, prednisolone, and clarithromycin+prednisolone groups than in the experimental group (p < 0.05). Furthermore, the histologic analyses showed histopathologic changes in the middle ear mucosa of the experimental group, but comparatively fewer-histopathologic changes were observed in the clarithromycin, prednisolone, and clarithromycin+prednisolone groups. |
| Anahtar Kelimeler |
| Otitis media with effusion | clarithromycin | prednisolone | antioxidant | cytokines | guinea pigs |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ACTA OTO-LARYNGOLOGICA |
| Dergi ISSN | 0001-6489 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2015 |
| Cilt No | 135 |
| Sayı | 10 |
| Sayfalar | 978 / 984 |
| Doi Numarası | 10.3109/00016489.2015.1058526 |
| Makale Linki | http://www.tandfonline.com/doi/full/10.3109/00016489.2015.1058526 |
| Atıf Sayıları | |
| WoS | 6 |
| Google Scholar | 10 |
