Effect of systemic clarithromycin and prednisolone on histamine induced otitis media in guinea pigs
Yazarlar (6)
Günay Kozan Türkiye
Bülent Aktan Atatürk Üniversitesi, Türkiye
Muhammed Sedat Sakat Atatürk Üniversitesi, Türkiye
Sezgin Kurt Kafkas Üniversitesi, Türkiye
Doç. Dr. Fatih ÖNER Kastamonu Üniversitesi, Türkiye
Adem Kara Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ACTA OTO-LARYNGOLOGICA (Q3) | ||
| Dergi ISSN | 0001-6489 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2015 |
| Cilt / Sayı / Sayfa | 135 / 10 / 978–984 | DOI | 10.3109/00016489.2015.1058526 |
| Makale Linki | http://www.tandfonline.com/doi/full/10.3109/00016489.2015.1058526 | ||
| Özet |
| Conclusion The results of the study showed that clarithromycin has anti-inflammatory and antioxidant effects and, when it is combined with prednisolone, those effects gain strength. Objectives The present study aims to investigate the effects that the antioxidant and anti-inflammatory activities of clarithromycin and/or prednisolone have on experimental otitis media in effusion-induced guinea-pigs. Method and results In this study, 35-male guinea pigs were randomly divided into five-groups. For the experimental otitis media, intra-tympanic histamine (0.1 ml) was injected into the guinea pigs in all of the groups except the control group. Then, 24-h after the intra-tympanic injections, clarithromycin (15 mg/kg/day) and/or prednisolone (1 mg/kg/day) were applied intraperitoneally to the guinea-pigs for 7-days. The biochemical analysis showed an increase in antioxidant capacity and a decrease in oxidant status and … |
| Anahtar Kelimeler |
| Otitis media with effusion | clarithromycin | prednisolone | antioxidant | cytokines | guinea pigs |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 7 |
| Google Scholar | 11 |