An investigation of the endoplasmic reticulum stress in obesity exposure in the prenatal period
Yazarlar (4)
Doç. Dr. Kıymet Kübra TÜFEKCİ Kastamonu Üniversitesi, Türkiye
Doç. Dr. Musa TATAR Kastamonu Üniversitesi, Türkiye
Doç. Dr. Funda TERZİ Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Chemical Neuroanatomy (Q3) | ||
| Dergi ISSN | 0891-0618 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2023 |
| Cilt / Sayı / Sayfa | 134 / 8 / 1–11 | DOI | 10.1016/j.jchemneu.2023.102348 |
| Makale Linki | http://dx.doi.org/10.1016/j.jchemneu.2023.102348 | ||
| Özet |
| ObjectivesExposure to maternal obesity has been shown to make offspring more prone to cognitive and metabolic disorders later in life. Although the underlying mechanisms are unclear, the role of endoplasmic reticulum (ER) stress in the fetal programming process is remarkable. ER stress can be activated by many chronic diseases, including obesity and diabetes. Therefore, our study aimed to investigate the role of ER stress caused by maternal diet-induced obesity in the offspring hippocampus. We also evaluated the protective effect of N-acetylcysteine (NAC) against ER stress.MethodsA rat obesity model was created by providing a high-fat (60 % kcal) diet. N-acetylcysteine (NAC) was administered at a dosage of 150 mg/kg via the intragastric route. The animals were mated at the age of 12 weeks. The same diet was maintained during pregnancy and lactation. The experiment was terminated on the postnatal … |
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| Google Scholar | 3 |