Expression of placental growth factor and a disintegrin and metalloprotease with a thrombospondin type motifs 1‐4‐8 during the three trimesters of rat pregnancy at the maternal‐fetal interface
Yazarlar (3)
Doç. Dr. Musa TATAR Kastamonu Üniversitesi, Türkiye
Sema Uslu Sivas Cumhuriyet Üniversitesi, Türkiye
Jale Öner Burdur Mehmet Akif Ersoy Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Anatomia, Histologia, Embryologia (Q3)
Dergi ISSN 0340-2096 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili Türkçe Basım Tarihi 07-2023
Cilt / Sayı / Sayfa 52 / 5 / 805–814 DOI 10.1111/ahe.12948
Makale Linki http://dx.doi.org/10.1111/ahe.12948
Özet
The functional roles of the a disintegrin and metalloprotease with a thrombospondin type motifs (ADAMTS) gene family in reproductive physiology, reproductive organs developments and adult reproductive health are still under investigation. The expression of the anti‐angiogenic proteases ADAMTS‐1, ADAMTS‐4 and ADAMTS‐8 in placental angiogenesis at various stages of pregnancy also remains unclear. The purpose of this study was therefore to determine the localization and expression of the ADAMTS‐1, ADAMTS‐4 and ADAMTS‐8 proteins during the three stages of pregnancy in rats. Maternal‐fetal tissue samples were collected on Days 5, 12 and 19 of each trimester, corresponding to the first, second and third trimesters. The expression of placental growth factor (PlGF) and ADAMTS‐1, ADAMTS‐4 and ADAMTS‐8 at the maternal‐fetal interface was examined using immunohistochemistry and western …
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