Oleuropein Mitigates Acrylamide-Induced Nephrotoxicity by Affecting Placental Growth Factor Immunoactivity in the Rat Kidney
Yazarlar (2)
Doç. Dr. Kıymet Kübra TÜFEKCİ Kastamonu Üniversitesi, Türkiye
Doç. Dr. Musa TATAR Kastamonu Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | The Eurasian Journal of Medicine | ||
| Dergi ISSN | 1308-8742 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | ESCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2023 |
| Cilt / Sayı / Sayfa | 55 / 3 / 228–233 | DOI | 10.5152/eurasianjmed.2023.23043 |
| Makale Linki | https://www.eajm.org/en/oleuropein-mitigates-acrylamide-induced-nephrotoxicity-by-affecting-placental-growth-factor-immunoactivity-in-the-rat-kidney-133495 | ||
| Özet |
| Objective Oleuropein is one of the main components of the antioxidant properties of olive leaves. Placental growth factor is an important regulator in angiogenesis and inflammation, its levels being variable in pathological conditions. In this study, we aimed to examine changes in placental growth factor expression and the effect of oleuropein, found in olive leaves, in rats exposed to acrylamide nephrotoxicity. Material and Methods Twenty-four male Wistar albino rats were allocated into 4 groups. The control group received saline solution only. The oleuropein group received oleuropein (4.2 mg/kg), the acrylamide group received acrylamide (5 mg/kg), and the acrylamide and oleuropein group received acrylamide (5 mg/kg) and oleuropein (4.2 mg/kg). All substances were administered via gastric gavage for 21 days. Kidney tissues were removed at the end of the study and subjected to histopathological, stereological … |
| Anahtar Kelimeler |
| Stereology | nephrotoxicity | placental growth factor | Cavalieri volume estimation |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 13 |