Protective and therapeutic role of melatonin against tunicamycin-induced ER stress in testicular tissue of rats
Yazarlar (2)
Doç. Dr. Musa TATAR Kastamonu Üniversitesi, Türkiye
Ülker Eren Aydın Adnan Menderes Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES (Q3) | ||
| Dergi ISSN | 2008-3866 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2022 |
| Cilt / Sayı / Sayfa | 25 / 2 / 214–223 | DOI | 10.22038/IJBMS.2022.58719.13043 |
| Makale Linki | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124527/ | ||
| Özet |
| Objective(s): This study aimed to investigate the possible consequences of administering exogenous melatonin as prevention or treatment against tunicamycin-induced endoplasmic reticulum (ER) stress in the testicular tissue of rats. Materials and Methods In this study, 42 adult Sprague Dawley rats, randomly divided into seven equal groups, were administered intraperitoneal tunicamycin to induce ER stress. Both prophylactic (PMel) and therapeutic melatonin (TMel) groups were administered melatonin for seven days. ER stress in the cell was detected through immunohistochemical and molecular analyses using GPR78 expression. Results Increased oxidant levels and apoptosis rates were shown in testicular tissue because of ER stress. The sections in the melatonin-administered and control groups were similar, with melatonin-administered groups showing an increase in the antioxidant ratio. Histometric … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 8 |