Alpha-lipoic acid modulates the diabetes mellitus-mediated neuropathic pain via inhibition of the TRPV1 channel, apoptosis, and oxidative stress in rats
Yazarlar (3)
Dr. Öğr. Üyesi Betül YAZĞAN Kastamonu Üniversitesi, Türkiye
Doç. Dr. Yener YAZĞAN Kastamonu Üniversitesi, Türkiye
Mustafa Nazıroğlu Süleyman Demirel Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Bioenergetics and Biomembranes (Q2) | ||
| Dergi ISSN | 0145-479X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2023 |
| Cilt / Sayı / Sayfa | 55 / 3 / 179–193 | DOI | 10.1007/s10863-023-09971-w |
| Makale Linki | https://link.springer.com/article/10.1007/s10863-023-09971-w | ||
| Özet |
| Diabetes mellitus (DM) is a chronic syndrome involving neuropathic pain. Increased oxidative stress in DM is assumed to increase free reactive oxygen radicals (ROS) and causes diabetic damage. The sciatic nerve (ScN) and dorsal root ganglion (DRG) both contain high levels of the TRPV1 channel, which is triggered by capsaicin and ROSs and results in increased Ca2+ entry into the neurons. Alpha-lipoic acid (ALA) is considered an important part of the antioxidant system. To better characterize the protective effects of ALA on the DM-induced neuronal through TRPV1 modulation, we investigated the role of ALA on DM-induced neuropathic pain, oxidative ScN, and DRG damage in diabetic rats. Forty adult Wistar albino female rats were divided into four groups as control, ALA (50 mg/kg for 14 days), streptozotocin (STZ and 45 mg/kg and single dose), and STZ + ALA. Rats were used for the pain tests. After … |
| Anahtar Kelimeler |
| Alpha-lipoic acid | Apoptosis | Neuropathic pain | Oxidative stress | TRPV1 channel |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 18 |
| Scopus | 20 |
| Google Scholar | 26 |