| Yazarlar (3) |
Dr. Öğr. Üyesi Betül YAZĞAN
Kastamonu Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Yener YAZĞAN
Kastamonu Üniversitesi, Türkiye |
Mustafa Nazıroğlu
Süleyman Demirel Üniversitesi, Türkiye |
| Özet |
| Diabetes is a common chronic metabolic disease worldwide. It causes diabetes, tissue degenerations, cell death and associated functional disability. Diabetes also causes the development of common diseases such as cardiovascular and nervous diseases. The most important pathophysiological mechanisms that are accepted in describing diabetic degenerative processes are oxidative stress damage (El-Refaei et al. 2014). Neuropathic pain is induced by several factors including inflammation, excessive Ca2+ influx, oxidative stress and tissue degeneration. Inflammatory reactions in destroying neurons lead to the activation of the pain molecular pathway. In addition, destruction cell membranes induce excessive Ca2+ entry in the neurons, because the Ca2+ concentration is about 10.000 times higher in out of the neurons than in the inside of the neuron. Overload Ca2+ influx into cytosol and it leads to excessive production of ROS in the neurons. Alpha lipoic acid (ALA) is an important member of the thiol cycle because it is containing the sulfur groups. It is powerful antioxidant substance and it can prevent the complications of diabetes (Ghibu et al. 2009). Transient receptor potential (TRP) channels have six subfamilies and 28 members in human. Most of these channels are responsible in dorsal root ganglia (DRG) neurons for the Ca2+ permeation especially in neuronal cells. Expression level of the TRPV1 channels is high in the DRG neurons and they show oxidative stress dependent activation. The TRPV1 channel expression levels in the DRG increased in different types of pain. Forty female rats were divided into four groups: First group was … |
| Anahtar Kelimeler |
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) |
| Makale Alt Türü | SCOPUS dergilerinde yayınlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | Journal of Cellular Neuroscience and Oxidative Stress |
| Dergi ISSN | 2149-7222 Scopus Dergi |
| Dergi Tarandığı Indeksler | SCOPUS |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2018 |
| Cilt No | 10 |
| Sayı | 3 |
| Sayfalar | 796 / |
| Makale Linki | https://dergipark.org.tr/tr/download/article-file/791917 |
