Protective effects of a natural product, paeoniflorin, on ischemia reperfusion injury on rat ovary tissue: histopathological, immunohistochemical, and biochemical study
Yazarlar (6)
Pınar Bayram Kafkas Üniversitesi, Türkiye
Selina Aksak Karameşe Kafkas Üniversitesi, Türkiye
Doç. Dr. Hüseyin Serkan Erol Kastamonu Üniversitesi, Türkiye
Bengül Özdemir Kafkas Üniversitesi, Türkiye
Erdem Toktay Kafkas Üniversitesi, Türkiye
Arş. Gör. Dr. Çağatay SALUM Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF HISTOTECHNOLOGY (Q4) | ||
| Dergi ISSN | 0147-8885 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 10-2023 |
| Cilt / Sayı / Sayfa | 46 / 4 / 170–183 | DOI | 10.1080/01478885.2023.2227409 |
| Makale Linki | http://dx.doi.org/10.1080/01478885.2023.2227409 | ||
| Özet |
| In this study, the main hypothesis is that paeoniflorin may inhibit some cellular processes such as oxidative stress and inflammation. For this reason, we aimed to investigate the potential protective effects of a natural compound, paeoniflorin, on rat model of ovarian ischemia-reperfusion injury by detecting the oxidative stress parameters and inflammatory process parameters. 42 female Wistar-albino rats were divided into 6 random groups. The rats were subjected to 3-hour ischemia and 3-hour reperfusion process. Then, paeoniflorin at doses of 25, 50 and 100 mg/kg were applied 30 min before the reperfusion. The levels of pro-inflammatory (IL-1-β, IL-6, TNF-α) and anti-inflammatory (IL-10, TGF-β) cytokines were measured by ELISA. Similarly, IL-6, IL-10, TNF-α, NF-κB p65) positivity rates were detected by immunohistochemical staining. Additionally, oxidative stress parameters (MDA, GSH, SOD) were measured … |
| Anahtar Kelimeler |
| Inflammation | ischemia-reperfusion injury | ovarian ischemia | oxidative stress | paeoniflorin |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Google Scholar | 6 |