| Yazarlar |
Doç. Dr. Funda TERZİ
Türkiye |
Dr. Öğr. Üyesi Beste DEMİRCİ
Türkiye |
Ümit Acar
Türkiye |
Arş. Gör. Dr. Süleyman YÜKSEL
Türkiye |
Arş. Gör. Çağatay SALUM
Türkiye |
Doç. Dr. Hüseyin Serkan EROL
Türkiye |
Doç. Dr. Osman Sabri KESBİÇ
Türkiye |
| Özet |
| The major goal of this study was to determine the effect of grape seed extract (GSE) on liver damage in rainbow trout (Oncorhynchus mykiss) that was caused by the consumption of dietary oxidized fish oil (OFO). Rainbow trout were fed six different experimental diets coded OX-GSE 0 (OFO diet), OX-GSE 1 (OFO and 0.1% GSE), OX-GSE 3 (OFO and 0.3% GSE), GSE 0 (fresh fish oil and 0.0% GSE), GSE 1 (fresh fish oil and 0.1% GSE), and GSE 3 (fresh fish oil and 0.3% GSE) for 30 days. The lowest % hepatosomatic index (HSI) result was calculated in fish fed with OX-GSE 0 and the highest HSI was determined in fish fed with GSE 1 diets (p < 0.05). Histopathologically, hydropic degeneration in hepatocytes significantly increased OX-GSE 0 and GSE 3 compared to GSE 1 diets (p < 0.05). Deposition of lipid droplets in hepatocytes was significantly increased in OX-GSE 0 and OX-GSE 3 groups than others (p < 0.05). Liver biochemistry parameters such as superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA) were significantly affected by OX and GSE treatments (p < 0.05). There were significant differences in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) among the liver enzymes analyzed in serum in OX and GSE (p < 0.05), meanwhile no difference was observed in lactate dehydrogenase (LDH) values between groups (p > 0.05). In conclusion, liver biochemistry and histopathology of rainbow trout consuming diets containing oxidized fish oil were negatively affected. However, it was determined that the supplementation of 0.1% GSE to the diet had a significant ameliorative role in these adverse effects. |
| Anahtar Kelimeler |
| Antioxidant capacity | Grape seed extract | Liver biochemistry | Oxidative stress | Oxidized oil |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | FISH PHYSIOLOGY AND BIOCHEMISTRY |
| Dergi ISSN | 0920-1742 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | Türkçe |
| Basım Tarihi | 06-2023 |
| Cilt No | 49 |
| Sayı | 3 |
| Sayfalar | 441 / 454 |
| Doi Numarası | 10.1007/s10695-023-01193-6 |
| Makale Linki | http://dx.doi.org/10.1007/s10695-023-01193-6 |
| Atıf Sayıları | |
| WoS | 9 |
| Google Scholar | 11 |
