Two flavonoids, baicalein and naringin, are effective as anti-inflammatory and anti-oxidant agents in a rat model of polymicrobial sepsis
Yazarlar (6)
Pınar Bayram Kafkas Üniversitesi, Türkiye
Selina Aksak Karameşe Kafkas Üniversitesi, Türkiye
Bengül Özdemir Kafkas Üniversitesi, Türkiye
Arş. Gör. Dr. Çağatay SALUM Kastamonu Üniversitesi, Türkiye
Doç. Dr. Hüseyin Serkan Erol Kastamonu Üniversitesi, Türkiye
Murat Karameşe Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (Q2) | ||
| Dergi ISSN | 0892-3973 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 09-2023 |
| Cilt / Sayı / Sayfa | 45 / 5 / 597–606 | DOI | 10.1080/08923973.2023.2197143 |
| Makale Linki | http://dx.doi.org/10.1080/08923973.2023.2197143 | ||
| Özet |
| IntroductionIn this study, our aim was to investigate the possible protective and therapeutic effects of these two flavonoids, baicalein, and naringin, in 50 and 100 mg/kg doses applied both before and after cecal ligation and puncture (CLP) procedures in a polymicrobial sepsis rat model, and evaluate the possible contribution of oxidative and inflammatory markers by immunological, biochemical, molecular, and histopathological methods.MethodsSixty-six Wistar albino rats were divided into 11 groups. The pro-inflammatory (TNF-alpha, IL-1-beta, and IL-6) and anti-inflammatory (TGF-beta and IL-10) cytokine levels were measured by ELISA technique. CD3, CD68, and nuclear factor kappa B positivity rates were detected by immunohistochemical methods. Oxidative stress parameters (MDA, SOD, and GSH) were measured by tissue biochemistry.ResultsSepsis caused a significant increase in all pro-inflammatory … |
| Anahtar Kelimeler |
| CLP | IL-6 | Sepsis | TNF-alpha | baicalein | flavonoids | inflammation | naringin | oxidative stress |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 18 |
| Google Scholar | 22 |