| Yazarlar |
Dr. Öğr. Üyesi Ali İNALTEKİN
Türkiye |
Yüksel Kıvrak
Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye |
| Özet |
| Introduction: Vortioxetine is an antidepressant that has a multimadal action mechanism and has recently come into use. The present study was planned to determine whether vortioxetine affects pain threshold in mice. Method: The experimental animals were divided into four groups with 10 mice in each group. The distilled water was given to the control group, 5 mg/kg of vortioxetine was intraperitoneally administered to the first group, 10 mg/kg of vortioxetine was intraperitoneally administered to the second group and 20 mg/kg of vortioxetine was intraperitoneally administered to the third group. Mice were placed on a hot-plate at 30 and 90 minutes. Hind paw licking and jumping times of the mice on the hot plate surface (55°C) were recorded.. Results: With increasing dose (0 mg p>0.05, 5 mg p<0.001, 10 mg p<0.001, 20 mg p<0.001) and increasing time (30th minute p<0.01, 90th minute p<0.01), it was observed that the reaction time per minute, which was a reflection of pain treshold was decreased. Conclusion: The results of this study shows that vortioxetine may have a decreasing effect on pain threshold in mice. Further studies are needed to determine the mechanism by which vortioxetine exerts its hyperalgesic effect. |
| Anahtar Kelimeler |
| Animal experiments | Nociception | Pain | Pain threshold | Vortioxetine |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY |
| Dergi ISSN | 1300-0667 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | Türkçe |
| Basım Tarihi | 12-2021 |
| Cilt No | 58 |
| Sayı | 4 |
| Sayfalar | 274 / 277 |
| Doi Numarası | 10.29399/npa.27462 |
| Makale Linki | https://www.noropsikiyatriarsivi.com/sayilar/2021/aralik//58_4/tr/npa_58_4_274-277.pdf |
| Atıf Sayıları | |
| WoS | 9 |
| SCOPUS | 7 |
| Google Scholar | 13 |
