Tert expression in pituitary adenomas
Yazarlar (11)
Nuray Can Trakya Üniversitesi, Türkiye
Mehmet Çelık Trakya Üniversitesi, Türkiye
Buket Yılma Z Bülbül Trakya Üniversitesi, Türkiye
Necdet Süt Trakya Üniversitesi, Türkiye
Filiz Özyilmaz Trakya Üniversitesi, Türkiye
Semra Aytürk Trakya Üniversitesi, Türkiye
Semra Güldıken Trakya Üniversitesi, Türkiye
Dr. Öğr. Üyesi Nurtaç SARIKAŞ Trakya Üniversitesi, Türkiye
Fulya Öz Puyan Trakya Üniversitesi, Türkiye
Tülin Deniz Yalta Trakya Üniversitesi, Türkiye
Ali Kemal Kutlu Trakya Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
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| Dergi Adı | Turk Patoloji Dergisi | ||
| Dergi ISSN | 1018-5615 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | Emerging Sources Citation Index | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2017 |
| Cilt / Sayı / Sayfa | 33 / 2 / 103–111 | DOI | 10.5146/tjpath.2016.01387 |
| Makale Linki | http://dx.doi.org/10.5146/tjpath.2016.01387 | ||
| UAK Araştırma Alanları |
Tıbbi Patoloji
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| Özet |
| Objective: Although pituitary adenomas have benign histomorphological features, some of them may present in an aggressive manner. To predict the behaviour of these tumours, telomerase reverse transcriptase (TERT) activity in pituitary adenomas has been the subject of a few studies with contradictory results. This study aims to investigate whether immunohistochemical expression of TERT differs in neoplastic and nonneoplastic pituitary tissues and aims to investigate whether TERT expression is related to clinicopathological features of pituitary adenomas. Material and Method: The study included 48 patients who had been diagnosed with pituitary adenomas and had clinical follow-ups. Nonneoplastic pituitary tissues were obtained from autopsy specimens (n=20). Immunohistochemistry for TERT antibody was performed. Both the nuclear and cytoplasmic expression of TERT antibody was noted, and total combined TERT staining was evaluated according to nuclear and cytoplasmic stainings. Results: TERT expression did not differ between neoplastic and nonneoplastic pituitary tissues. Neither total (combined nuclear and cytoplasmic) TERT nor nuclear TERT expression revealed any statistically significant relationship with any of the clinicopathological features. Higher cytoplasmic TERT expression was observed in adenomas with recurrence than adenomas without recurrence (p=0.035). Conclusion: This study introduces the notion that immunohistochemical expression of TERT does not differ in neoplastic and nonneoplastic pituitary tissues. Pituitary adenomas with cytoplasmic immunohistochemical expression of TERT have significantly higher rates of recurrence. Further studies, including combined methods of immunohistochemistry and molecular analyses in larger groups, may reveal applicable results for the clinical significance of TERT in pituitary adenomas. |
| Anahtar Kelimeler |
| Clinicopathological features | Pituitary adenomas | Telomerase reverse transcriptase |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 3 |