CD56, CD57, HBME1, CK19, Galectin-3 and p63 immunohistochemical stains in differentiating diagnosis of thyroid benign/malign lesions and NIFTP
Yazarlar (8)
Ebru Taştekin Trakya Üniversitesi, Türkiye
Fatma Elif Usturalı Keskin Türkiye
Prof. Dr. Nuray Can Trakya Üniversitesi, Türkiye
Şule Canberk Türkiye
Ezgi Genç Erdoğan Türkiye
Dr. Öğr. Üyesi Nurtaç SARIKAŞ Kastamonu Üniversitesi, Türkiye
Yavuz Atakan Sezer Trakya Üniversitesi, Türkiye
Meltem Azatçam Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | POLISH JOURNAL OF PATHOLOGY (Q4) | ||
| Dergi ISSN | 1233-9687 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2019 |
| Cilt / Sayı / Sayfa | 70 / 4 / 286–294 | DOI | 10.5114/PJP.2019.93131 |
| Makale Linki | http://dx.doi.org/10.5114/pjp.2019.93131 | ||
| UAK Araştırma Alanları |
Tıbbi Patoloji
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| Özet |
| Detection of thyroid carcinoma has been steadily increased in the past few decades. After the recognition of NIFTP, also gain importance to differentiate benign tumors (follicular adenoma) from follicular patterned variants of papillary thyroid carcinoma (invasive and infiltrative follicular variant papillary thyroid carcinoma), and low-risk lesions of thyroid (NIFTP). Follicular patterned proliferations of thyroid still persists as a battle for pathologists. In this study, we aimed to analyze the most commonly used immunohistochemical stains "HBME1, CK19, Galectin-3", adding the new ones "CD56, CD57, and p63". Study groups were; nodular hyperplasia, follicular adenoma, NIFTP, infiltrative follicular variant PTC, classical variant PTC (CVPTC) and follicular carcinoma. Each group consisted of twenty cases. The sections were stained with CD56, CD57, p63, CK19, HBME1 (Mesotel cell), Galectin-3 antibody. Although the expression of CD56 was high in benign follicular lesions, FC could not be excluded in this group. CD57 was high in malignant follicular group and NIFTP. Interestingly, p63 was found highly expressed in FVPTC, which might be promising to predict invasiveness in follicular group of lesions. CK19, Galectin-3 and HBME1 were found quietly prominent in CVPTC in concordance with the previous reports. |
| Anahtar Kelimeler |
| thyroid lesions | differential diagnosis | CK19 | Galectin-3 | CD56 | CD57 | p63 | HBME1 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 15 |