| Yazarlar |
Muhammad Mujtaba
|
|
Bahar Akyüz Yılmaz
|
|
Demet Cansaran Duman
Türkiye |
|
Lalehan Akyüz
Aksaray Üniversitesi, Türkiye |
|
Sevcan Yangın
|
|
Murat Kaya
Aksaray Üniversitesi, Türkiye |
Prof. Dr. Talip ÇETER
Kastamonu Üniversitesi, Türkiye |
|
Khalid Mahmood Khawar
|
| Özet |
| Sporopollenin-mediated control drug delivery has been studied extensively owing to its desirable physicochemical and biological properties. Herein, sporopollenin was successfully extracted from C. libani and P. nigra pollens followed by loading of a commonly known anticancer drug Oxaliplatin. Drug loading and physicochemical features were confirmed by using light microscopy, FT-IR, SEM and TGA. For the first-time, real-time cell analyzer system xCELLigence was employed to record the Oxaliplatin loaded sporopollenin-mediated cell death (CaCo-2 and Vero cells) in real time. Both the release assays confirmed the slow release of oxaliplatin from sporopollenin for around 40–45 h. The expression of MYC and FOXO-3 genes has been significantly increased in CaCo2 cell and decreased non-cancerous Vero cell confirming the fact that sporopollenin-mediated control release of oxaliplatin is promoting apoptosis cell death preventing the spread of negative effects on nearby healthy cells. All the results suggested that C. libani and P. nigra can be suitable candidates for the slow delivery of drugs. |
| Anahtar Kelimeler |
| Controlled-drug release | Real-time cell analyzer | Sporopollenin | xCELLigence |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Polymer Bulletin |
| Dergi ISSN | 0170-0839 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2022 |
| Cilt No | 79 |
| Sayfalar | 519 / 540 |
| Doi Numarası | 10.1007/s00289-020-03531-7 |
| Makale Linki | http://dx.doi.org/10.1007/s00289-020-03531-7 |
| Atıf Sayıları | |
| SCOPUS | 2 |
