Newly isolated sporopollenin microcages from Cedrus libani and Pinus nigra as carrier for Oxaliplatin; xCELLigence RTCA-based release assay
Yazarlar (8)
Muhammad Mujtaba
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Dr. Öğr. Üyesi Bahar Akyüz Yılmaz Aksaray Üniversitesi, Türkiye
Prof. Dr. Demet Cansaran Duman Ankara Üniversitesi, Türkiye
Doç. Dr. Lalehan Akyüz Aksaray Üniversitesi, Türkiye
Sevcan Yangın
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Prof. Dr. Murat Kaya Aksaray Üniversitesi, Türkiye
Prof. Dr. Talip ÇETER Kastamonu Üniversitesi, Türkiye
Khalid Mahmood Khawar
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Polymer Bulletin (Q3) | ||
| Dergi ISSN | 0170-0839 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2022 |
| Cilt / Sayı / Sayfa | 79 / 1 / 519–540 | DOI | 10.1007/s00289-020-03531-7 |
| Makale Linki | http://dx.doi.org/10.1007/s00289-020-03531-7 | ||
| UAK Araştırma Alanları |
Bitki Morfolojisi ve Anatomisi
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| Özet |
| Sporopollenin-mediated control drug delivery has been studied extensively owing to its desirable physicochemical and biological properties. Herein, sporopollenin was successfully extracted from C. libani and P. nigra pollens followed by loading of a commonly known anticancer drug Oxaliplatin. Drug loading and physicochemical features were confirmed by using light microscopy, FT-IR, SEM and TGA. For the first-time, real-time cell analyzer system xCELLigence was employed to record the Oxaliplatin loaded sporopollenin-mediated cell death (CaCo-2 and Vero cells) in real time. Both the release assays confirmed the slow release of oxaliplatin from sporopollenin for around 40–45 h. The expression of MYC and FOXO-3 genes has been significantly increased in CaCo2 cell and decreased non-cancerous Vero cell confirming the fact that sporopollenin-mediated control release of oxaliplatin is promoting … |
| Anahtar Kelimeler |
| Controlled-drug release | Real-time cell analyzer | Sporopollenin | xCELLigence |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 5 |
| Google Scholar | 9 |