Controlled release and anti-proliferative effect of imatinib mesylate loaded sporopollenin microcapsules extracted from pollens of Betula pendula
Yazarlar (9)
Idris Sargin Aksaray Üniversitesi, Türkiye
Doç. Dr. Lalehan Akyüz Aksaray Üniversitesi, Türkiye
Prof. Dr. Murat Kaya Aksaray Üniversitesi, Türkiye
Doç. Dr. Gamze Tan Aksaray Üniversitesi, Türkiye
Prof. Dr. Talip ÇETER Kastamonu Üniversitesi, Türkiye
Kevser Yildirim
Aksaray Üniversitesi, Türkiye
Aksaray Üniversitesi, Türkiye
Seymanur Ertosun
Aksaray Üniversitesi, Türkiye
Aksaray Üniversitesi, Türkiye
Gozde Hatun Aydin
Aksaray Üniversitesi, Türkiye
Aksaray Üniversitesi, Türkiye
Müge Topal
Aksaray Üniversitesi, Türkiye
Aksaray Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | International Journal of Biological Macromolecules (Q1) | ||
| Dergi ISSN | 0141-8130 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2017 |
| Cilt / Sayı / Sayfa | 105 / 1 / 749–756 | DOI | 10.1016/j.ijbiomac.2017.07.093 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0141813016319602 | ||
| UAK Araştırma Alanları |
Bitki Morfolojisi ve Anatomisi
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| Özet |
| Sporopollenin is a promising material for drug encapsulation due to its excellent properties; uniformity in size, non-toxicity, chemically and thermally resilient nature. Herein, morphologically intact sporopollenin microcapsules were extracted from Betula pendula pollens. Cancer therapeutic agent (imatinib mesylate) was loaded into the microcapsules. The encapsulation efficiency by passive loading technique was found to be 21.46%. Release behaviour of the drug from microcapsules was found to be biphasic, with an initial fast release followed by a slower rate of release. Imatinib mesylate release from the drug itself (control) was faster than from imatinib mesylate-loaded sporopollenin microcapsules. The release profiles for both free and entrapped drug samples were significantly slower and more controlled in PBS buffer (pH 7.4) than in HCl (pH 1.2) buffer. Cumulative drug release from IM-MES-loaded … |
| Anahtar Kelimeler |
| Encapsulation | Microcapsule | Oral drug delivery | Pollen |
Science Direct
Controlled release and anti-proliferative effect of imatinib mesylate loaded sporopollenin microcapsules extracted from pollens of Betula pendula
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 39 |
| Scopus | 41 |
| Google Scholar | 49 |