Pl3K/Akt/NF-κB Signalling Pathway on NSCLC Invasion
Yazarlar (3)
Dr. Öğr. Üyesi Hakan KÜÇÜKSAYAN Kastamonu Üniversitesi, Türkiye
Şakir Akgün Kafkas Üniversitesi, Türkiye
Hakan Akça Pamukkale Üniversitesi, Türkiye
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) (Uluslararası alan indekslerindeki dergilerde yayınlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale) | ||
| Dergi Adı | Medicinal Chemistry | ||
| Dergi ISSN | 2161-0444 | ||
| Dergi Tarandığı Indeksler | CAS Source Index | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2016 |
| Cilt / Sayı / Sayfa | 6 / 4 / 234–238 | DOI | 10.4172/2161-0444.1000351 |
| Makale Linki | http://dx.doi.org/10.4172/2161-0444.1000351 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Invasion is a crucial step of metastasis process that has a complex mechanism and inducible various cellular signalling pathway (SMADs, JAK/STATs, PI3K/Akt and MAP kinases). In among these pathways, Pl3K (phosphatidylinositol-3-OH kinase)/Akt/NF-ĸB (nuclear factor-ĸB) signalling pathway is an important on cellular invasion and its constitutively active in various human cancer, including non-small cell lung cancer (NSCLC). PI3K/Akt/NF-ĸB pathway has been associated with multiple cellular function; migration, apoptosis, proliferation, survival, and also differentiation. Thus, this signalling pathway plays a major role not only in tumorigenesis but also in a potential target for cancer treatment. It has been investigated that there are lots of observation about Pl3K/Akt signalling pathway on many cancers, especially NSCLC. But, it is not enough to completely understanding the molecular mechanism of NSCLC invasion. In this review, we will briefly discuss the molecular mechanism of PI3K/Akt/NF-ĸB signalling pathway in NSCLC invasion. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 21 |