The dicyano compound induces autophagic or apoptotic cell death via Twist/c-Myc axis depending on metastatic characteristics of breast cancer cells
Yazarlar (6)
Özge Alvur Van Yüzüncü Yıl Üniversitesi, Türkiye
Dr. Öğr. Üyesi Hakan KÜÇÜKSAYAN Kastamonu Üniversitesi, Türkiye
Yasemin Bayğu Pamukkale Üniversitesi, Türkiye
Nilgün Kabay Pamukkale Üniversitesi, Türkiye
Prof. Dr. Yaşar Gök Usak University, Ermenistan
Prof. Dr. Hakan Akça Pamukkale Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Molecular Biology Reports | ||
| Dergi ISSN | 0301-4851 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 11-2022 |
| Cilt / Sayı / Sayfa | 49 / 1 / 39–50 | DOI | 10.1007/s11033-021-06817-9 |
| Makale Linki | http://dx.doi.org/10.1007/s11033-021-06817-9 | ||
| Özet |
| BackgroundBreast cancer (BC) is a heterogeneous disease with various subtypes, therefore, the illumination of distinctive mechanisms between subtypes for the development of novel treatment strategies is important. Here, we revealed the antiproliferative effects of our customized dicyano compound (DC) on BC cells.Methods and resultsWe determined the antiproliferative effect of the DC on non-metastatic MCF-7 and metastatic MDA-MB-231 cell lines by MTT. We evaluated protein levels of LC3BI-II and p62 to detect effects of the DC on autophagy. Furthermore, we examined whether the DC induce apoptosis in MCF-7 and MDA-MB-231 cells by performing TUNEL and western blotting. We showed that the DC induces autophagic cell death in MDA-MB-231 while it leads to apoptosis in MCF-7, demonstrating that DC can induce different cell death mechanisms in BC cells according to what they represent subtypes … |
| Anahtar Kelimeler |
| Apoptosis | Autophagy | c-Myc | EMT | Twist |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 5 |
| Google Scholar | 5 |