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Newly isolated sporopollenin microcages from Platanus orientalis pollens as a vehicle for controlled drug delivery     
Yazarlar
Muhammad Mujtaba
Idrıs Sargın
Lalehan Akyüz
Aksaray Üniversitesi, Türkiye
Prof. Dr. Talip ÇETER
Kastamonu Üniversitesi, Türkiye
Murat Kaya
Aksaray Üniversitesi, Türkiye
Özet
Sporopollenin microcages were produced from the pollens of Platanus orientalis. Paracetamol was loaded into the microcages. Pollen, sporopollenin, paracetamol and paracetamol-loaded sporopollenin microcages were characterized with FT-IR, TGA and SEM. The analytical analyses demonstrated that sporopollenin microcages were structurally intact, highly reticulated and thermally stable. The loading efficiency of the sporopollenin microcages was found to be 8.2% using the passive loading technique and 23.7% via evaporating loading technique. In vitro release and kinetics studies were performed to test the suitability of sporopollenin microcages for loading. These studies revealed that sporopollenin from P. orientalis can be suggested as a suitable carrier for drug loading and controlled release studies.
Anahtar Kelimeler
Release kinetics,Drug delivery,Microcapsule,Acetaminophen
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Materials Science Engineering C-Materials for Biological Applications
Dergi ISSN 0928-4931
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 03-2017
Cilt No 77
Sayfalar 263 / 270
Doi Numarası 10.1016/j.msec.2017.02.176