| Yazarlar |
Ömer Araz
Türkiye |
|
Elif Yılmazel Uçar
Türkiye |
|
Aslıhan Yalçın
|
Dr. Öğr. Üyesi Nazlı EROL
Türkiye |
|
Mehmet Meral
Türkiye |
|
Ali Metin Görgüner
Türkiye |
|
Metin Akgün
Türkiye |
| Özet |
| The diagnostic utility of novel biomarkers in patients with suspected pulmonary embolism (PE) is still under investigation. While many studies emphasize that high serum levels of high-sensitivity C-reactive protein (Hs-CRP) has a moderate relation with PE, few studies show that Hs-CRP can be used to predict the outcome of the treatment. In this study, we aimed to determine whether there is a relationship between serum levels of Hs-CRP and reperfusion of pulmonary tissue. As a secondary objective, the correlation between Hs-CRP and subgroups of PE was investigated. A total of 85 patients with PE, 38 male (44.7%) and 47 female (55.3%) with an average age of 65.5 ± 13.4, were included in this prospective observational study. Samples of blood were collected before and 48 h after the inception of fibrinolytic therapy. The correlation of changes in serum Hs-CRP levels with reperfusion duration was statistically significant (r = 0.548, P = 0.01). Second, we found that some subgroups of PE (massive PE: r = 0.719, P = 0.001, and minor PE: r = 0.529, P = 0.001) had a relation with changes in serum Hs-CRP levels, whereas some had none (submassive PE: r = 0.136, P = 0.215). Changes in serum Hs-CRP levels can be a potential predictor of the outcomes for patients with PE. Additionally, this value of change can notify the presence of some subgroups of PE (massive and minor PE). |
| Anahtar Kelimeler |
| Hs-CRP | acute pulmonary embolism | fibrinolytic therapy | reperfusion duration |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | The Clinical Respiratory Journal |
| Dergi ISSN | 1752-6981 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2014 |
| Cilt No | 10 |
| Doi Numarası | 10.1111/crj.12196 |
| Makale Linki | http://dx.doi.org/10.1111/crj.12196 |
| Atıf Sayıları |
