Tyrosol improves ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation
Yazarlar (9)
Mustafa Cellat Hatay Mustafa Kemal Üniversitesi, Türkiye
Müslüm Kuzu Karabük Üniversitesi, Türkiye
Prof. Dr. Cafer Tayer İşler Hatay Mustafa Kemal Üniversitesi, Türkiye
Dr. Öğr. Üyesi Muhammed ETYEMEZ Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Nursel Dikmen Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Ahmet Uyar Hatay Mustafa Kemal Üniversitesi, Türkiye
Dr. Öğr. Üyesi İshak Gökçek Hatay Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Erdinç Türk Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. Mehmet Güvenç Mustafa Kemal Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Naunyn Schmiedeberg S Archives of Pharmacology (Q2) | ||
| Dergi ISSN | 0028-1298 Dergi Bilgileri (2021) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2021 |
| Kabul Tarihi | 23-06-2021 | Yayınlanma Tarihi | 21-07-2021 |
| Cilt / Sayı / Sayfa | 394 / 10 / 2061–2075 | DOI | 10.1007/s00210-021-02117-y |
| Makale Linki | http://dx.doi.org/10.1007/s00210-021-02117-y | ||
| UAK Araştırma Alanları |
Veteriner Fizyolojisi
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| Özet |
| Asthma is an inflammatory disease that affects many people around the world, especially persons at paediatric age group. The effectiveness of tyrosol, a natural phenolic compound, was examined in the asthma model induced by ovalbumin (OVA). For this purpose, four groups, each consisting of eight rats, were arranged. For 21 days, physiological saline solution was treated to the control group and OVA was treated to the groups of OVA, OVA + dexamethasone (Dexa) and OVA + tyrosol groups, intraperitoneally and through inhalation. Additionally, 0.25 mg/kg Dexa was treated to the OVA + Dexa group and 20 mg/kg tyrosol to the OVA + tyrosol group by oral gavage. Serum, blood, bronchoalveolar lavage fluid (BALF) and lung tissues of the rats were examined. It was observed that MDA level decreased, GSH level and GPx activity increased, and there was no change in CAT activity in lung tissues of the … |
| Anahtar Kelimeler |
| Anti-allergic | Anti-inflammatory | Antioxidant | Asthma | Tyrosol |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 30 |
| Scopus | 34 |
| Google Scholar | 38 |