Carvacrol showed a curative effect on reproductive toxicity caused by Bisphenol AF via antioxidant, anti-inflammatory and anti-apoptotic properties
Yazarlar (8)
Doç. Dr. Ahmet Uyar Hatay Mustafa Kemal Üniversitesi, Türkiye
Mustafa Cellat Hatay Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Özgür Kanat Necmettin Erbakan Üniversitesi, Türkiye
Dr. Öğr. Üyesi Muhammed ETYEMEZ Kastamonu Üniversitesi, Türkiye
Doç. Dr. Tuncer Kutlu Hatay Mustafa Kemal Üniversitesi, Türkiye
Mehmet Yılmaz Zeki Deveci
Mustafa Kemal Üniversitesi, Türkiye
Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. İlker Yavaş Hatay Mustafa Kemal Üniversitesi, Türkiye
Müslüm Kuzu Karabük Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Reproductive Toxicology (Q1) | ||
| Dergi ISSN | 0890-6238 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 10-2023 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-10-2023 |
| Cilt / Sayı / Sayfa | 121 / 1 / – | DOI | 10.1016/j.reprotox.2023.108456 |
| Makale Linki | http://dx.doi.org/10.1016/j.reprotox.2023.108456 | ||
| UAK Araştırma Alanları |
Veteriner Fizyolojisi
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| Özet |
| Bisphenol AF (BPAF) is an endocrine disruptor, and human exposure to these chemicals is growing in industrialized nations. BPAF has been demonstrated in studies to have toxic effects on reproductive health. This study examined the effects of oral exposure to BPAF on the reproductive system and the protective effects of carvacrol in rats. From 32 Wistar albino rats, four separate groups were set up for this purpose. Carvacrol 75 mg/kg and BPAF 200 mg/kg were administered by oral gavage method. Rat sperm parameters and serum testosterone levels were measured after 28 days of administration. The study looked at the MDA in the testis tissues, as well as CAT, GPx, and GSH as antioxidants parameters, NF-κB and TNF-α as inflammatory markers, caspase-3 and Bcl-2 as apoptosis parameters, and PCNA as cell proliferation markers. In addition, testis tissues underwent histological evaluation. As a result, in rats … |
| Anahtar Kelimeler |
| Antioxidant | Apoptosis | Bisphenol AF | Carvacrol | Infertility | Inflammation |
Science Direct
Carvacrol showed a curative effect on reproductive toxicity caused by Bisphenol AF via antioxidant, anti-inflammatory and anti-apoptotic properties
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 12 |
| Google Scholar | 14 |