Inula viscosa ameliorates acetic acid induced ulcerative colitis in rats
Yazarlar (9)
Mustafa Cellat Hatay Mustafa Kemal Üniversitesi, Türkiye
İbrahim Ozan Tekeli Türkiye
Doç. Dr. Erdinç Türk Hatay Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. Tuba Aydın Ağrı İbrahim Çeçen Üniversitesi, Türkiye
Doç. Dr. Ahmet Uyar Hatay Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. Cafer Tayer İşler Hatay Mustafa Kemal Üniversitesi, Türkiye
Dr. Öğr. Üyesi İshak Gökçek Hatay Mustafa Kemal Üniversitesi, Türkiye
Dr. Öğr. Üyesi Muhammed ETYEMEZ Kastamonu Üniversitesi, Türkiye
Prof. Dr. Mehmet Güvenç Hatay Mustafa Kemal Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | BIOTECHNIC & HISTOCHEMISTRY (Q4) | ||
| Dergi ISSN | 1052-0295 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 05-2023 |
| Cilt / Sayı / Sayfa | 98 / 4 / 255–266 | DOI | 10.1080/10520295.2023.2176923 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/10520295.2023.2176923 | ||
| Özet |
| Increased pro-inflammatory cytokines and oxidative stress contribute to the pathophysiology of ulcerative colitis (UC). is a plant with antioxidant and anti-inflammatory properties. We investigated the effect of an ethanolic extract of on an experimental UC model created using acetic acid. Rats were divided into four groups of eight: group 1, control; group 2, 3% acetic acid group; group 3, 100 mg/kg sulfasalazine + 3% acetic acid group; group 4, 400 mg/kg + 3% acetic acid. and sulfasalazine were administered by oral gavage and 3% acetic acid was administered per rectum. We found that treatment decreased colon malondialdehyde, tumor necrosis factor-α, interleukin-1 beta and nuclear factor kappa B levels; it increased reduced glutathione, nuclear factor erythroid 2-related factor 2, heme oxygenase-1 and kelch-like ECH-associated protein 1 levels and glutathione peroxidase enzyme activity. Group 1 colon exhibited normal histological structure. Slight inflammatory cell infiltration and edema and insignificant slight erosion in crypts were detected in colon tissues of group 4. We found that reduced oxidative stress and inflammation, which was protective against UC by inducing the Nrf-2/Keap-1/HO-1 pathway in the colon. |
| Anahtar Kelimeler |
| Acetic acid | antioxidant | inflammation | Inula viscosa | rats | ulcerative colitis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 4 |