| Yazarlar |
Mustafa Cellat
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
İbrahim Ozan Tekeli
Türkiye |
|
Erdinç Türk
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Tuba Aydın
Ağrı İbrahim Çeçen Üniversitesi, Türkiye |
|
Ahmet Uyar
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Cafer Tayer İşler
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
İshak Gökçek
Hatay Mustafa Kemal Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Muhammed ETYEMEZ
Kastamonu Üniversitesi, Türkiye |
|
Mehmet Güvenç
Hatay Mustafa Kemal Üniversitesi, Türkiye |
| Özet |
| Increased pro-inflammatory cytokines and oxidative stress contribute to the pathophysiology of ulcerative colitis (UC). is a plant with antioxidant and anti-inflammatory properties. We investigated the effect of an ethanolic extract of on an experimental UC model created using acetic acid. Rats were divided into four groups of eight: group 1, control; group 2, 3% acetic acid group; group 3, 100 mg/kg sulfasalazine + 3% acetic acid group; group 4, 400 mg/kg + 3% acetic acid. and sulfasalazine were administered by oral gavage and 3% acetic acid was administered per rectum. We found that treatment decreased colon malondialdehyde, tumor necrosis factor-α, interleukin-1 beta and nuclear factor kappa B levels; it increased reduced glutathione, nuclear factor erythroid 2-related factor 2, heme oxygenase-1 and kelch-like ECH-associated protein 1 levels and glutathione peroxidase enzyme activity. Group 1 colon exhibited normal histological structure. Slight inflammatory cell infiltration and edema and insignificant slight erosion in crypts were detected in colon tissues of group 4. We found that reduced oxidative stress and inflammation, which was protective against UC by inducing the Nrf-2/Keap-1/HO-1 pathway in the colon. |
| Anahtar Kelimeler |
| Acetic acid | antioxidant | inflammation | Inula viscosa | rats | ulcerative colitis |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | BIOTECHNIC & HISTOCHEMISTRY |
| Dergi ISSN | 1052-0295 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2023 |
| Cilt No | 98 |
| Sayı | 4 |
| Sayfalar | 12 / 266 |
| Doi Numarası | 10.1080/10520295.2023.2176923 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/10520295.2023.2176923 |
| Atıf Sayıları | |
| WoS | 1 |
