The effect of tyrosol on diclofenac sodium-induced acute nephrotoxicity in rats
Yazarlar (9)
Doç. Dr. Mehmet Çömez Türkiye
Mustafa Cellat Hatay Mustafa Kemal Üniversitesi, Türkiye
Müslüm Kuzu Karabük Üniversitesi, Türkiye
Doç. Dr. Ahmet Uyar Hatay Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Erdinç Türk Hatay Mustafa Kemal Üniversitesi, Türkiye
Yusuf Selim Kaya
Türkiye
Türkiye
Dr. Öğr. Üyesi Muhammed ETYEMEZ Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi İshak Gökçek Hatay Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. Mehmet Güvenç Hatay Mustafa Kemal Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (Q2) | ||
| Dergi ISSN | 1095-6670 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2024 |
| Cilt / Sayı / Sayfa | 38 / 1 / 9–0 | DOI | 10.1002/jbt.23582 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/full/10.1002/jbt.23582 | ||
| Özet |
| Although diclofenac (DCF) is a nonsteroidal anti-inflammatory drug that is considered safe, its chronic use and overdose may show some toxic effects. The protective effect of tyrosol (Tyr) pretreatment against DCF-induced renal damage was investigated in this study. The 32 rats used in the study were randomly divided into four groups of eight rats each. According to the data obtained, it was determined that creatinine, urea, and blood urea nitrogen (BUN) levels increased in serum samples of the DCF group. Besides, the levels of reduced glutathione (GSH) and glutathione peroxidase (GPx) activity decreased and the malondialdehyde (MDA) level increased in the kidney tissue. However, no change was observed in catalase (CAT) activity. Cyclooxygenase-2 (COX-2), nuclear factor kappa B (NF-κB), and tumor necrosis factor-alpha (Tnf-α) levels increased and nuclear factor erythroid 2-related factor 2 (Nrf-2) levels decreased. No change was detected in the level of interleukin 1 beta (IL-1β). When the DCF+Tyr group and the DCF group were compared, it was assessed that Tyr had a curative effect on all biochemical parameters. Also, kidney damages, such as degeneration and necrosis of tubular epithelium and congestion of veins, were obviated by treatment with tyrosol in histopathological examinations. It was determined that Tyr pretreatment provided a protective effect against nephrotoxicity induced by DCF with its anti-inflammatory and antioxidant properties. |
| Anahtar Kelimeler |
| anti-inflammatory | antioxidant | diclofenac | nephrotoxicity | tyrosol |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 10 |