Safranal's therapeutic effects in rat models of polycystic ovary syndrome
Yazarlar (8)
Mustafa Cellat Hatay Mustafa Kemal Üniversitesi, Türkiye
Müslüm Kuzu Karabük Üniversitesi, Türkiye
Prof. Dr. Mehmet Güvenç Hatay Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. Murat Yüksel Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Özgür Kanat Necmettin Erbakan Üniversitesi, Türkiye
Prof. Dr. Yeşim Akaydın Bozkurt Mustafa Kemal Üniversitesi, Türkiye
Dr. Öğr. Üyesi Muhammed ETYEMEZ Kastamonu Üniversitesi, Türkiye
Prof. Dr. Fikret Karaca Mustafa Kemal Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Revista Brasileira De Farmacognosia (Q3) | ||
| Dergi ISSN | 1981-528X Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 04-2024 |
| Kabul Tarihi | 27-10-2023 | Yayınlanma Tarihi | 15-11-2023 |
| Cilt / Sayı / Sayfa | 34 / 2 / 301–312 | DOI | 10.1007/s43450-023-00484-6 |
| Makale Linki | https://link.springer.com/article/10.1007/s43450-023-00484-6 | ||
| UAK Araştırma Alanları |
Veteriner Fizyolojisi
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| Özet |
| Polycystic ovary syndrome is one of the leading causes of female infertility in reproductive age. In this work, the protective effects of safranal against letrozole-induced polycystic ovary syndrome in rats were examined. For this purpose, 32 Wistar albino female rats were split into four groups. Each group received the following treatments for 21 days: Group 1 received carboxymethylcellulose (1%, 2 ml/kg); Group 2, letrozole (1 mg/kg), Group 3, safranal (200 mg/kg); and Group 4 letrozole and safranal via oral gavage. We identified estrus cycles in the rats and analyzed various parameters in their serum and ovarian tissues, as well as histopathologic findings. The parameters studied included C-reactive protein, glucose, total cholesterol, triacylglyceride, high-density lipoprotein, low-density lipoprotein, follicle-stimulating hormone, estradiol, and luteinizing hormone levels in serum. Additionally, the study measured … |
| Anahtar Kelimeler |
| Herbal medicine | Hyperandrogenism | Inflammation | Oxidative stress | Phytochemical |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 2 |
| Google Scholar | 5 |