Investigation of the effects of safranal on the experimentally created rheumatoid arthritis model in rats
Yazarlar (7)
Doç. Dr. Mustafa Cellat Mustafa Kemal Üniversitesi, Türkiye
Cafer T. İşler
Mustafa Kemal Üniversitesi, Türkiye
Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Tuncer Kutlu Mustafa Kemal Üniversitesi, Türkiye
Müslüm Kuzu Karabük Üniversitesi, Türkiye
Dr. Öğr. Üyesi Muhammed ETYEMEZ Mustafa Kemal Üniversitesi, Türkiye
Dr. Öğr. Üyesi Halil Alakuş Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. Mehmet Güvenç Mustafa Kemal Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Biochemical and Molecular Toxicology (Q2) | ||
| Dergi ISSN | 1095-6670 Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 09-2022 |
| Kabul Tarihi | 30-05-2022 | Yayınlanma Tarihi | 08-06-2022 |
| Cilt / Sayı / Sayfa | 36 / 9 / – | DOI | 10.1002/jbt.23140 |
| Makale Linki | http://dx.doi.org/10.1002/jbt.23140 | ||
| UAK Araştırma Alanları |
Veteriner Fizyolojisi
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| Özet |
| Rheumatoid arthritis (RA) is a systemic chronic disease characterized by inflammation and synovitis. More effective treatment methods with less side effects need to be developed. In this context, current study investigated the therapeutic effects of safranal in a model of complete Freund's adjuvant (CFA)‐induced RA. The control group was given 1 ml of saline orally starting from the 8th day, and 0.2 ml of CFA was given to the RA, RA + Safranal and RA + Methotrexate (MTX) groups on the 0th day of the experiment. Starting from the 8th day of the experiment, 1 ml of saline was given to the RA group, safranal was given at 200 mg/kg of body weight to the RA + MTX group, and 3 mg/kg of MTX to the RA + MTX group twice a week. The results showed that weight gain decreased in the RA group compared to the control group while arthritis index score, thymus index, and planter temperature were found to … |
| Anahtar Kelimeler |
| anti-inflammatory | arthritis index | oxidative stress | saffron | synovitis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 6 |
| Scopus | 7 |
| Google Scholar | 8 |