Protective effect of Smilax excelsa L. pretreatment via antioxidant, anti‐inflammatory effects, and activation of Nrf‐2/HO‐1 pathway in testicular torsion model
Yazarlar (9)
Mustafa Cellat Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. Cafer Tayer İşler Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Ahmet Uyar Mustafa Kemal Üniversitesi, Türkiye
Müslüm Kuzu Karabük Üniversitesi, Türkiye
Prof. Dr. Tuba Aydın Aǧrı İbrahim Çeçen Üniversitesi, Türkiye
Dr. Öğr. Üyesi Muhammed ETYEMEZ Hatay Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Erdinç Türk Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. İlker Yavaş Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. Mehmet Güvenç Mustafa Kemal Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Food Biochemistry (Q2) | ||
| Dergi ISSN | 0145-8884 Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2022 |
| Kabul Tarihi | 15-03-2022 | Yayınlanma Tarihi | 29-03-2022 |
| Cilt / Sayı / Sayfa | 46 / 8 / – | DOI | 10.1111/jfbc.14161 |
| Makale Linki | http://dx.doi.org/10.1111/jfbc.14161 | ||
| UAK Araştırma Alanları |
Veteriner Fizyolojisi
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| Özet |
| The protective effects of the ethanol extract of Smilax excelsa L. (SE) leaves were investigated on testicular tissue of rats with a torsion model in this study. The chemical composition of the extract was detected by means of liquid chromatography with tandem mass spectrometry (LC–MS/MS). SE extract was given for 21 days before torsion was created in the treatment group. The sperm parameters of the torsion group were impaired, and there was an increase in MDA level as well as a decrease in GSH level and GPx activity compared to the control group. TNF‐α and NF‐κB levels in the torsion group increased as compared to those in the control group. The expression levels of Nrf‐2 and HO‐1 were lower in the torsion group than those in the control group. The SE pretreatment group has improved sperm, oxidative stress, and inflammatory markers when compared to the torsion group, and the Nrf‐2/HO‐1 pathway … |
| Anahtar Kelimeler |
| inflammation | oxidative stress | Smilax excelsa L. | testis torsion |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 21 |
| Google Scholar | 25 |