Ameliorative Effects of Oleuropein on Lipopolysaccharide-Induced Acute Lung Injury Model in Rats
Yazarlar (7)
Nursel Dikmen Hatay Mustafa Kemal Üniversitesi, Türkiye
Mustafa Cellat Hatay Mustafa Kemal Üniversitesi, Türkiye
Dr. Öğr. Üyesi Muhammed ETYEMEZ Hatay Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. Cafer Tayer İşler Hatay Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Ahmet Uyar Hatay Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. Tuba Aydın Türkiye
Prof. Dr. Mehmet Güvenç Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | INFLAMMATION (Q3) | ||
| Dergi ISSN | 0360-3997 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2021 |
| Cilt / Sayı / Sayfa | 44 / 6 / 2246–2259 | DOI | 10.1007/s10753-021-01496-x |
| Makale Linki | http://dx.doi.org/10.1007/s10753-021-01496-x | ||
| Özet |
| Acute lung injury (ALI) is one of the most common causes of death in diseases with septic shock. Oleuropein, one of the important components of olive leaf, has antioxidant and anti-inflammatory effects. The objective of this study was to investigate the effects of oleuropein on lipopolysaccharide (LPS)-induced ALI in rats. Oleuropein was administered to rats at a dose of 200 mg/kg for 20 days and LPS was given through intratracheal administration to induce ALI. The study was terminated after 12 h. The results showed that in the group treated with oleuropein, inflammatory cytokines and oxidative stress decreased in serum, bronchoalveolar lavage fluid (BALF), and lung tissue, and there were significant improvements in the picture of acute interstitial pneumonia (AIP) caused by LPS in histopathological examination. Based on the findings of the present study, oleuropein showed protective effects against LPS-induced ALI. |
| Anahtar Kelimeler |
| oleuropein | lung injury | lipopolysaccharide |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 23 |