| Yazarlar |
Nursel Dikmen
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Mustafa Cellat
Hatay Mustafa Kemal Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Muhammed ETYEMEZ
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Cafer Tayer İşler
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Ahmet Uyar
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Tuba Aydın
Türkiye |
|
Mehmet Güvenç
Türkiye |
| Özet |
| Acute lung injury (ALI) is one of the most common causes of death in diseases with septic shock. Oleuropein, one of the important components of olive leaf, has antioxidant and anti-inflammatory effects. The objective of this study was to investigate the effects of oleuropein on lipopolysaccharide (LPS)-induced ALI in rats. Oleuropein was administered to rats at a dose of 200 mg/kg for 20 days and LPS was given through intratracheal administration to induce ALI. The study was terminated after 12 h. The results showed that in the group treated with oleuropein, inflammatory cytokines and oxidative stress decreased in serum, bronchoalveolar lavage fluid (BALF), and lung tissue, and there were significant improvements in the picture of acute interstitial pneumonia (AIP) caused by LPS in histopathological examination. Based on the findings of the present study, oleuropein showed protective effects against LPS-induced ALI. |
| Anahtar Kelimeler |
| oleuropein | lung injury | lipopolysaccharide |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Inflammation |
| Dergi ISSN | 0360-3997 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2021 |
| Cilt No | 44 |
| Sayı | 6 |
| Sayfalar | 2246 / 2259 |
| Doi Numarası | 10.1007/s10753-021-01496-x |
| Makale Linki | http://dx.doi.org/10.1007/s10753-021-01496-x |
| Atıf Sayıları | |
| WoS | 10 |
