Histopathological, immunohistochemical and biochemical alterations in liver tissue after fungicide-mancozeb exposures in Wistar albino rats
Yazarlar (2)
Doç. Dr. Ertuğrul GÖK Dicle Üniversitesi, Türkiye
Engin Deveci Dicle Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Acta Cirurgica Brasileira (Q4) | ||
| Dergi ISSN | 0102-8650 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2022 |
| Cilt / Sayı / Sayfa | 37 / 4 / – | DOI | 10.1590/acb370404 |
| Makale Linki | https://www.scielo.br/j/acb/a/4gn7rRSzd3Dy7nB4DNLG8Pf/?format=pdf&lang=en | ||
| Özet |
| Purpose To evaluate the histopathological, immunohistochemical, and biochemical effects of liver changes after mancozeb administration. Methods Rats were divided into groups–the control group (n=7) and the mancozeb group (n=7)–, given 500 mg/kg mancozeb dissolved in corn oil daily for four weeks by an orogastric tube. Caspase-3 and tumor necrosis factor-alpha (TNF-α) primary antibodies were used for immunohistochemical analysis. Results Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values of the mancozeb group increased significantly than ones of the control group. Venous dilatation, inflammation, hepatocyte degeneration, TNF-α, and caspase-3 expression scores increased significantly in the mancozeb group. In the mancozeb group, intensive caspase-3 expression was observed in hepatocyte cells around the central vein in the center of the liver lobule, and there was an increase in TNF-α expression in the inflammatory cells around the enlarged central vein and Kupffer cells and apoptotic hepatocyte cells. Conclusions Subacute mancozeb exposure in rats leads to elevated toxicity with impaired liver function, increased inflammation in tissue and increased apoptosis due to cellular damage in the liver, and decreased liver regeneration ability due to congestion and degeneration of blood vessels. |
| Anahtar Kelimeler |
| Immunohistochemistry | Liver | Toxicity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 13 |
| Scopus | 16 |
| Google Scholar | 25 |