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Impact of inflammatory markers on the prognosis of patients with operable breast cancer    
Yazarlar
Ibrahim Petekkaya
Sercan Aksoy
Emir C. Roach
Alexis K. Okoh
Gizen Gecmez
Gamze Gezgen
Deniz C. Isler
Erkan Dogan
Taner Babacan
Furkan Sarici
Emine Petekkaya
Kadri Altundag
Özet
To investigate the effect of inflammatory markers on the prognosis of patients with operable breast cancer. This study was conducted on breast cancer patients followed up between December 2009 and December 2012 at the Division of Medical Oncology, Department of Internal Medicine, Hacettepe University Medical School. A total of 704 patients with stages I to III disease whose inflammatory markers were assessed at the time of diagnosis were included the study. Serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), albumin, ferritin, β2 microglobulin (β2-M), and lactate dehydrogenase (LDH) levels were evaluated as inflammatory markers. The median age at diagnosis was 50 years (range 25-92). Of the patients 42.8% were premenopausal and 48.2 % postmenopausal. Invasive ductal carcinoma was the most common histology (76.5 %). Serum ferritin, LDH, β2-M, ESR, and CRP were higher than the normal values in 1.0, 4.3, 9.5, 32.4 and 36.4 % of the patients, respectively. Serum albumin levels were lower than the normal values in 1.7 % of the patients. The median patient follow-up period was 22 months (range 3-227). During follow-up, metastatic disease developed in 31 patients (4.4%) and 11 patients (1.56%) died due to disease progression. Two-year overall survival (OS) and disease free survival (DFS) rates were not statistically different among patients with normal and abnormal values with respect to albumin, ferritin, LDH, β2-M, CRP, and ESR. Our study is the first study to investigate the effect of inflammatory markers on the prognosis of operable breast cancer patients. We showed that inflammatory markers such as ESR, CRP, ferritin, β2-M, albumin and LDH have no effect on prognosis.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü ESCI dergilerinde yayımlanan tam makale
Dergi Adı JOURNAL OF BUON
Dergi ISSN 1107-0625
Makale Dili İngilizce
Basım Tarihi 70-2014
Cilt No 19
Sayı 3
Sayfalar 673 / 680
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
WoS 11

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