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Udder defense system: Effect of milk somatic cell countlevel on Th1/Th2 cytokine balance   
Yazarlar
Doç. Dr. Tarık ŞAFAK
Kastamonu Üniversitesi
Ali Risvanli
Özet
The immune system of the cow is kept strong to protect the cows from mastitis, which causes economic losses for dairy cattle herds. Cellular immunity, especially, plays an important role as a first-line defense system. In the case of inflammation, cytokines play a decisive role in monitoring this process. In this study, the relationship between somatic cell count (SCC) and cytokine (tumor necrosis factor alpha, interferon gamma, and interleukins TNF-α, IFN-γ,IL-2, -4, -5, and -10, respectively) concentrations in milk were determined. It was decided to support the humoral and cellular aspects of the udder defense system by determining the T-helper cell (Th1/Th2) cytokine polarization in high SCC milk from cows with signs of mastitis. Milk samples from 180 cows were divided into five groups according to the somatic cell count level (˂ 150 x 103, 151 x 103-400 x 103, 401 x 103-600x103, 601 x 103-1,000 x 103, and > 1,000x103 cells⁄mL). It was understood that the Th1 direction was determined before mastitis was formed, that is when SCC was low (˂ 150 x 103). As a result, it was concluded that theTh1 polarization should be supported to protect cows from mastitis.
Anahtar Kelimeler
Bovine mastitis,Somatic cell count,Th1/Th2 cytokine
Makale Türü Özgün Makale
Makale Alt Türü ESCI dergilerinde yayımlanan tam makale
Dergi Adı JOURNAL OF THE HELLENIC VETERINARY MEDICAL SOCIETY
Dergi ISSN 1792-2720
Makale Dili İngilizce
Basım Tarihi 40-2022
Cilt No 73
Sayı 2
Sayfalar 4135 / 4140
Doi Numarası 10.12681/jhvms.26718