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Evaluation of Apparent Diffusion Coefficients in the Cerebellar Tonsils and Bulbus in Chiari Type I Malformations: Comparison Before and After Surgery     
Yazarlar
Bekir Akgun
Sait Ozturk
Dr. Öğr. Üyesi İsmail TAŞKENT
Kastamonu Üniversitesi
Mehmet Besir Surme
Fatih Serhat Erol
Hanefi Yildirim
Özet
AIM: To evaluate the preoperative and postoperative 6th month mean apparent diffusion coefficient (ADC) values of the cerebellar tonsils and bulbus in patients with Chiari Malformation Type I (CMI), and to compare the results with healthy controls. MATERIAL and METHODS: We included 15 patients with CMI who underwent suboccipital decompression, upper cervical laminectomy, and duraplasty surgery, and compared them with 10 healthy individuals. Three regions of interest were placed, one each in the cerebellar tonsils and one in the bulbus. The mean ADC values were measured separately in each region. RESULTS: Among the patients, mean ADC values were significantly decreased after surgery compared with before surgery. The mean ADC values before surgery were significantly higher for patients than for controls; however, although the mean ADC values were slightly higher after surgery for patients than for controls, the differences were not significant. Thus, after surgical intervention, ADC values in patients with CMI became close to those of normal individuals. CONCLUSION: The increased ADC values in patients with CMI before surgery implied that not only morphologic changes but also increased diffusivity may play a key role in the pathophysiology and clinical presentation of the disease. Decompression surgery can produce favorable diffusional alterations.
Anahtar Kelimeler
Apparent diffusion coefficient | Chiari malformation type 1 | Diffusion-weighted imaging | Suboccipital decompression
Makale Türü Özgün Makale
Makale Alt Türü ESCI dergilerinde yayımlanan tam makale
Dergi Adı TURKISH NEUROSURGERY
Dergi ISSN 1019-5149
Makale Dili İngilizce
Basım Tarihi 01-2018
Cilt No 28
Sayı 5
Sayfalar 710 / 715
Doi Numarası 10.5137/1019-5149.JTN.20326-17.1