Plasma and muscle tissue disposition of enrofloxacin in Nile tilapia (Oreochromis niloticus) after intravascular, intraperitoneal, and oral administrations

Çorum, Orhan; TERZİ, Ertuğrul; Üney, Kamil; Çorum, Duygu Durna; TAŞTAN, Yiğit; Gonzales, Ruby C.; KENANOĞLU, Osman Nezih; Arrıesgado, Dan M.; Navarro, Victor R.; BİLEN, Soner; SÖNMEZ, Adem Yavuz

doi:10.1080/19440049.2022.2121429

Plasma and muscle tissue disposition of enrofloxacin in Nile tilapia (Oreochromis niloticus) after intravascular, intraperitoneal, and oral administrations

Yazarlar (11)

Prof. Dr. Orhan Çorum Hatay Mustafa Kemal Üniversitesi, Türkiye

Doç. Dr. Ertuğrul TERZİ Kastamonu Üniversitesi, Türkiye

Doç. Dr. Duygu Durna Çorum University Of Hatay Mustafa Kemal, Türkiye

Arş. Gör. Dr. Yiğit TAŞTAN Kastamonu Üniversitesi, Türkiye

Ruby C. Gonzales
Mindanao State University At Naawan, Filipinler

Arş. Gör. Dr. Osman Nezih KENANOĞLU Kastamonu Üniversitesi, Türkiye

Dan M. Arrıesgado
Mindanao State University At Naawan, Filipinler

Victor R. Navarro
Mindanao State University At Naawan, Filipinler

Doç. Dr. Soner BİLEN Kastamonu Üniversitesi, Türkiye

Doç. Dr. Adem Yavuz SÖNMEZ Kastamonu Üniversitesi, Türkiye

Prof. Dr. Kamil Üney Selçuk Üniversitesi, Türkiye

Makale Türü	Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı	Food Additives and Contaminants Part A (Q2)
Dergi ISSN	1944-0049 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler	SCI-Expanded
Makale Dili	İngilizce	Basım Tarihi	09-2022
Cilt / Sayı / Sayfa	39 / 11 / 1806–1817	DOI	10.1080/19440049.2022.2121429
Makale Linki	https://doi.org/10.1080/19440049.2022.2121429
UAK Araştırma Alanları	Su Ürünleri Yetiştiriciliği

Özet

The aim of the study was to investigate the plasma and muscle pharmacokinetic of enrofloxacin (ENR) and its active metabolite ciprofloxacin (CIP) in Nile tilapia (Oreochromis niloticus) following single intravascular (IV), intraperitoneal (IP), or oral (PO) administration at 30 ± 1 °C. In this study, 234 healthy Nile tilapia (120–150 g) were used. The fish received a single IV, IP, or PO treatment of ENR at a dose of 10 mg/kg. The plasma and muscle tissue concentrations of ENR and CIP were measured using high–performance liquid chromatography with fluorescence detection and were evaluated using non–compartmental analysis. The elimination half–life, volume of distribution at steady state, and total body clearance of ENR were 21.7 h, 2.69 L/kg, and 0.09 L/h/kg, respectively. The peak plasma concentrations of ENR after IP or PO administration were 6.11 and 4.21 µg/mL at 0.25 and 2 h, respectively. The bioavailability of ENR for IP or PO routes was 78% and 86%, respectively. AUC(0–120)muscle/AUC(0–120)plasma ratios following the IV, IP, or PO administrations were 1.43, 1.49, and 1.07, respectively. CIP was detected after all routes, but the AUC0–last ratios of CIP to ENR were <1.0% for plasma and muscle. ENR was detected up to 120 h following the IV, IP, or PO administrations. The long residence time of ENR after single IV, IP, or PO administration ensured the plasma concentration was ≥1 × MIC for bacteria with threshold MIC values of 0.92, 0.72, and 0.80 μg/mL over the whole 120 h observed. However, further studies are necessary to determine the optimum pharmacokinetic/pharmacodynamics data of ENR for the treatment of infections caused by susceptible bacteria in tilapia.

Anahtar Kelimeler

bioavailability | enrofloxacin | muscle tissue | Pharmacokinetics | rainbow trout

BM Sürdürülebilir Kalkınma Amaçları

Atıf Sayıları
Scopus	21

Plasma and muscle tissue disposition of enrofloxacin in Nile tilapia (Oreochromis niloticus) after intravascular, intraperitoneal, and oral administrations

Dergi Adı	Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment
Yayıncı	Taylor and Francis Ltd.
Açık Erişim	Hayır
ISSN	1944-0049
E-ISSN	1944-0057
CiteScore	8,2
SJR	0,526
SNIP	1,014

Plasma and muscle tissue disposition of enrofloxacin in Nile tilapia (Oreochromis niloticus) after intravascular, intraperitoneal, and oral administrations

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