| Yazarlar |
Anna De Laet
University of East Anglia, Faculty of Social Sciences, United Kingdom |
|
Elena Serena Piccardi
Birkbeck, University of London, United Kingdom |
|
Jannath Begum-Ali
Birkbeck, University of London, United Kingdom |
|
Tony Charman
King's College London, United Kingdom |
|
Mark H. Johnson
Birkbeck, University of London, United Kingdom |
|
Emily J.H. Jones
Birkbeck, University of London, United Kingdom |
|
Rachael Bedford
University of Bath, United Kingdom |
|
Teodora Gliga
University of East Anglia, Faculty of Social Sciences, United Kingdom |
|
M. Agyapong
University of East London, United Kingdom |
|
Tessel Bazelmans
University of East London, United Kingdom |
|
Leila Dafner
Birkbeck, University of London, United Kingdom |
|
Mutluhan Ersoy
Kastamonu University, Turkey |
|
Amy Goodwin
University of East London, United Kingdom |
|
Rianne Haartsen
Birkbeck, University of London, United Kingdom |
|
Hanna Halkola
University of East London, United Kingdom |
|
Alexandra Hendry
University of Oxford Medical Sciences Division, United Kingdom |
|
Rebecca Holman
Birkbeck, University of London, United Kingdom |
|
Sarah Kalwarowsky
Birkbeck, University of London, United Kingdom |
|
Anna Kolesnik-Taylor
Birkbeck, University of London, United Kingdom |
|
Sarah Lloyd-Fox
University of Cambridge, United Kingdom |
|
Luke Mason
Birkbeck, University of London, United Kingdom |
|
Nisha Narvekar
University of East London, United Kingdom |
|
Greg Pasco
University of East London, United Kingdom |
|
Laura Pirazzoli
Boston Children's Hospital, United States |
|
Chloë Taylor
Birkbeck, University of London, United Kingdom |
| Özet |
| Sleep problems in Autism Spectrum Disorder (ASD) emerge early in development, yet the origin remains unclear. Here, we characterise developmental trajectories in sleep onset latency (SOL) and night awakenings in infants at elevated likelihood (EL) for ASD (who have an older sibling with ASD) and infants at typical likelihood (TL) for ASD. Further, we test whether the ability to gate tactile input, using an EEG tactile suppression index (TSI), associates with variation in SOL and night awakenings. Parent-reported night awakenings and SOL from 124 infants (97 at EL for ASD) at 5, 10 and 14 months were analyzed using generalized estimating equations. Compared to TL infants, infants at EL had significantly more awakenings and longer SOL at 10 and 14 months. The TSI predicted SOL concurrently at 10 months, independent of ASD likelihood status, but not longitudinally at 14 months. The TSI did not predict night awakenings concurrently or longitudinally. These results imply that infants at EL for ASD wake up more frequently during the night and take longer to fall asleep from 10 months of age. At 10 months, sensory gating predicts SOL, but not night awakenings, suggesting sensory gating differentially affects neural mechanisms of sleep initiation and maintenance. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SCOPUS dergilerinde yayımlanan tam makale |
| Dergi Adı | Scientific Reports |
| Dergi ISSN | 2045-2322 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2022 |
| Cilt No | 12 |
| Sayı | 1 |
| Doi Numarası | 10.1038/s41598-022-18018-w |
| Atıf Sayıları |
