| Yazarlar |
Fatih Oner
Kastamonu University, Turkey |
|
Gunay Kozan
Dicle University, Faculty of Medicine, Turkey |
|
Adem Kara
Erzurum Teknik Üniversitesi, Turkey |
| Özet |
| Objective: Allergic rhinitis is a chronic upper respiratory disease characterized by inflammation of the nose due to the accumulation of inflammatory cells. We aimed to investigate the therapeutic efficacy of capsaicin and/or steroids in reducing the symptoms, proinflammatory cytokine levels, and inflammatory cell infiltrations in an animal model of allergic rhinitis. Materials and Methods: Thirty-five male Wistar rats were divided into five groups. Following injection and initial intranasal challenge with ovalbumin, rats were treated with intraperitoneal capsaicin (50 mg/kg) and/or steroid (10 mg/kg) injection for seven days. After nasal symptom scorings, all rats were sacrificed under anesthesia, and blood samples and nasal septa were collected for hematologic, biochemical, and histopathologic examinations. Results: The ovalbumin challenge increased nasal symptom scores, eosinophil and basophil counts, the serum IL-4, IL-5, IL-13 and IL-33 levels, and histopathologic damage. Capsaicin and/or steroid administration attenuated the allergic rhinitis symptoms. There was a therapeutic effect of capsaicin and the combined use of capsaicin and steroids on experimentally-induced allergic rhinitis as reflected by decreases in allergic inflammation and secretion of cytokines. There was no difference between the CAPS, CAPS-STR, and STR groups in terms of allergic rhinitis symptoms. Conclusion: Parenteral administration of CAPS alone, and especially the combined use of CAPS and STR, effectively treats allergic rhinitis symptoms in a rat model of allergic rhinitis. Our results show that CAPS alone is not an effective alternative to STR but accelerates the recovery of allergic rhinitis. |
| Anahtar Kelimeler |
| Allergic rhinitis | capsaicin | ovalbumin | rat | steroid |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SCOPUS dergilerinde yayımlanan tam makale |
| Dergi Adı | Asthma Allergy Immunology |
| Dergi ISSN | 1308-9234 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2023 |
| Cilt No | 21 |
| Sayı | 3 |
| Sayfalar | 192 / 198 |
| Doi Numarası | 10.21911/aai.245 |
| Atıf Sayıları | |
| SCOPUS | 1 |
