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Exploring PGE2 and LXA4 Levels in Migraine Patients: The Potential of LXA4-Based Therapies      
Yazarlar
Dr. Öğr. Üyesi İdris KOCATÜRK
Kastamonu Üniversitesi, Türkiye
Doç. Dr. Sedat GÜLTEN
Kastamonu Üniversitesi, Türkiye
Doç. Dr. Bünyamin ECE
Kastamonu Üniversitesi, Türkiye
Prof. Dr. Fatma Mutlu KUKUL GÜVEN
Kastamonu Üniversitesi, Türkiye
Özet
Neurogenic inflammation plays a significant role in the pathogenesis of migraines. This study aimed to investigate the serum levels of prostaglandin E2 (PGE2), lipoxin A4 (LXA4), and other inflammatory biomarkers (C-reactive protein, fibrinogen) in migraine patients. In total, 53 migraine patients and 53 healthy controls were evaluated. Blood serum samples were collected during both attack and interictal periods and compared with the control group. In both the attack and interictal periods, PGE2 and LXA4 values were significantly lower in migraine patients compared to the control group (p < 0.001). Additionally, PGE2 values during the attack period were significantly higher than those during the interictal period (p = 0.016). Patients experiencing migraine attacks lasting ≥ 12 h had significantly lower serum PGE2 and LXA4 levels compared to those with attacks lasting < 12 h (p = 0.028 and p = 0.009, respectively). In ROC analysis, cut-off values of 332.7 pg/mL for PGE2 and 27.2 ng/mL for LXA4 were determined with 70–80% sensitivity and specificity. In conclusion, PGE2 and LXA4 levels are significantly lower in migraine patients during both interictal and attack periods. Additionally, the levels of LXA4 and PGE2 decrease more with the prolongation of migraine attack duration. Our findings provide a basis for future treatment planning.
Anahtar Kelimeler
C-reactive protein | fibrinogen | inflammation | lipoxin A4 | migraine | prostaglandin E2
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı DIAGNOSTICS
Dergi ISSN 2075-4418
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q1
Makale Dili Türkçe
Basım Tarihi 03-2024
Cilt No 14
Sayı 6
Sayfalar 635 / 646
Doi Numarası 10.3390/diagnostics14060635
Makale Linki http://dx.doi.org/10.3390/diagnostics14060635
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Exploring PGE2 and LXA4 Levels in Migraine Patients: The Potential of LXA4-Based Therapies

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