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The association between platelet/lymphocyte ratio and coronary artery disease severity   
Yazarlar
Murat Yüksel
Dicle Üniversitesi, Turkey
Prof. Dr. Abdulkadir YILDIZ
Kastamonu Üniversitesi, Türkiye
Mustafa Oylumlu
Dicle Üniversitesi, Turkey
Abdurrahman Akyüz
Dicle Üniversitesi, Turkey
Mesut Aydın
Dicle Üniversitesi, Turkey
Hasan Kaya
Dicle Üniversitesi, Turkey
Halit Acet
Dicle Üniversitesi, Turkey
Nihat Polat
Dicle Üniversitesi, Turkey
Mehmet Zihni Bilik
Dicle Üniversitesi, Turkey
Sait Alan
Dicle Üniversitesi, Turkey
Özet
Objective: In this study, we aimed to explore the association between platelet-to-lymphocyte ratio (PLR) and the severity of atherosclerosis in coronary artery disease (CAD). Methods: Clinical and laboratory data of 388 patients who underwent coronary angiography were evaluated retrospectively. Gensini score, which indicates the severity of atherosclerosis, was calculated for all of the patients. Patients with CAD were categorized as mild and severe atherosclerosis, according to their Gensini score. Eighty patients with normal coronary arteries formed the control group. Mean PLR values of the three study groups were compared. Also, PLR value was tested for whether it showed a positive correlation with Gensini score. Results: The mean PLR of the severe atherosclerosis group was significantly higher than that of the mild atherosclerosis and controls groups (p<0.001). Also, PLR was positively correlated with Gensini score in CAD patients. A cut-off value of 111 for PLR predicted severe atherosclerosis with 61% sensitivity and 59% specificity. Pre-procedural PLR level was found to be independently associated with Gensini score, together with WBC, age, and low HDL level, in the multivariate analysis. Conclusion: Our study suggests that high PLR appears to be additive to conventional risk factors and commonly used biomarkers in predicting severe atherosclerosis.
Anahtar Kelimeler
Atherosclerosis | Coronary artery disease | Gensini score | Platelet-lymphocyte ratio
Makale Türü Özgün Makale
Makale Alt Türü SCOPUS dergilerinde yayımlanan tam makale
Dergi Adı Anadolu Kardiyoloji Dergisi
Dergi ISSN 1302-8723
Makale Dili İngilizce
Basım Tarihi 08-2015
Cilt No 15
Sayı 8
Sayfalar 640 / 647
Doi Numarası 10.5152/akd.2014.5565
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
SCOPUS 36
The association between platelet/lymphocyte ratio and coronary artery disease severity

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